鼻咽癌调强放疗等效均匀剂量优化方法对腮腺的保护作用.pdfVIP

·484· ·论著· 鼻咽癌调强放疗等效均匀剂量优化方法 对腮腺的保护作用 乐文友戴建荣 高黎 【摘要】 目的探索等效均匀剂量(EUD)优化方法在鼻咽癌调强放疗中对腮腺的保护作用。 方法从已接受调强放疗的鼻咽癌患者中，随机抽取12例。这些患者的治疗计划均是采用物理约束 条件优化设计的。以这些计划为基础，将腮腺的物理约束条件改为EUD约束，而保持其他危及器官 和靶区的约束条件不变，为每位患者设计一个新的计划，并比较新旧治疗计划。结果在保证靶区和 其他危及器官受照剂量不变情况下，EUD优化能够使腮腺的平均剂量和V，。显著降低，经r检验，P 值都0．05。结论EUD优化能够降低腮腺的受照剂量，这对降低腮腺放疗并发症具有重要意义， 也为靶区加量提供了空间。 【关键词】 鼻咽肿瘤／放射疗法； 调强放射疗法； 等效均匀剂量； 辐射防护，腮腺 radiation for carcinoma euivalent Intensity-modulatedtherapynasopharyngealparotidsparing稍th uiformdose YUE optimizationWen-you，DAIJian-rong，GaoLi．DepartmentofRadiationOncology， Cancer Medical UnionMedical Hospital(Institute)，ChineseAcademyof Sciences，Peking College，Beijing 100021，China author：DAI CorrespondingJian-tong Theaimofthis wastoevaluatetheroleofaneuivalentuiformdose 【Abstract】Objective study (EUD)basedoptimization in the of with carcinoma algorithmsparingparotidspatientsnasopharyngeal aretreatedwith radiation 12 (NPC)whenthey intensity—modulatedtherapy(IMRT)．Methodspatients were selectedfromtheNPC who IMRT treat— receivedtreatments．Forthese randomly patients patients，the ment were with on plans designedphysicaloptimizationconstraints(dose／dose—volumeconstraints)．Based these were the constraintswithmaximumEUDfor plans，newplans designedthroughreplacingphysical pa— the for andother at rotids，whilekeepingphysicalobjectivestargets organsrisk(OARs)unchanged．Com— wasthenmadebetweenthenew hadEUDconstraintsto theformerfor parison