回归正交评价指标智能筛选法用于色谱分离条件的快速优化.pdfVIP

2015 年 2 月 Vol. 33 NO.2 色译 February 2015 Chinese lournal of Chromatography 140-145 研究论文 DOI: 10.3724/SP.J.1123.2014.09040 回归正交评价指标智能筛选法用于色谱分离条件的快速优化 甘伟l\ 刘学敏2 ，孙静1 (1.重庆市环境监测中心，重庆 401147; 2. 重庆惠能标普科技有限公司，重庆 401117) 摘要:建立了一种可用于包谱分离条件快速优化的回归正交评价指标智能筛选法。以串行色谱响应函数作为色i普 条件优化指标，利用回归正交试验设计建立回归筷犁，并通过最优解智能筛选程序对综合性优化指标进行筛选，最 终实现包谱分离条件的最优化。 结果表明:实验测定值与预测值的平均相对偏差为 0.18% ，优化结果理想。 关键词:回归正交评价指标智能筛选法;申行色谱响应函数:回归正交试验设计;色谱条件的优化;高效液相色谱法 sflOO分类号:0658 文献标i只码:A 文章编号: 1000-8713( 2015) 02-0140-06 Regression evalnation index intelligent filter method for quick optimization of chromatographic separation conditions l 2 l GAN Wei , LlU Xuemin , SUN Jing (1. Chongqing En饥ron饥entat Monitoring Center, Cho叼qi叼 401147 ， 侃侃a; 2. Cho叼qing Huineng Bia.opu Technology Co. , Ltd. , Chongq饥9 401117 , Ch侃α) Abstract : This paper presents a method of regression evaluation index intelligent fIlter method ( REIFM) for quick optimization of chromatographic separation conditions. The hierarchical chromatography response function was used as the chromatography-optimization index. The re- gression model was established by 0此hogonal regression design. The chromatography-optimiza- tion index was filtered by the intelligent filter program , and the optimization of the separation conditions was obtained. The experimental results showed that the average relative deviation between the experimental values and the predicted values was O. 18% at the optimum and the optimization results were sa