阿卡波糖和二甲双胍治疗糖耐量减低的疗效比较.pdfVIP

Joumal of Medical Forum Vo1．28 No．23 December 2007 阿卡波糖和二甲双胍 厶- ，口7-r 糖耐量减低的疗效比较 吕红霞 深圳市罗湖区人民医院 深圳市 518001 摘要 目的 观察阿卡波糖和二甲双胍治疗糖耐量减低的疗效。方法 糖耐量减低患者82例，随机分 为两组，阿卡波糖组41例给予阿卡波糖50～100mg，3次／d；二甲双胍组41例给予盐酸二甲双胍250～500mg，3 ；L／d，疗程共l2个月。治疗前及疗程结束后测空腹及餐后2h血糖、血脂(总胆固醇、甘油三酯、高密度脂蛋白胆 固醇)和体重指数BMI。结果 治疗后两组空腹及餐后2h血糖较治疗前均显著下降(P0．05和P0．01)， 但对餐后2h血糖控制阿卡波糖组[(6．82±0．24)mmol／L]优于二甲双胍组[(7．85±0．42)mmol／L](P 0．01)。2组均有调节血脂功能，无显著差异。二甲双胍在减轻体重方面优于阿卡波糖(P0．05)。结论 阿 卡波糖和二甲双胍均能降低餐后血糖，并能调节血脂，可用于糖耐量减低的治疗。 关键词 阿卡波糖；二甲双胍；糖耐量减低 中图分类号：R977．1 5 文献标识码：B 文章编号：1672．3422(2007)23-0011-02 Effect of Acarbose and Metformin on Patients with Impaired Glucose Tolerance LU Hongxia Shenzhen Peoples Hospital ofLuohu District，Shenzhen 518001，China ABSTRACT Objective To observe the effect of acarbose and metfomfin on patients with im- paired glucose tolerance(IGT)．Methods Tofal 82 patients with IGT were randomly divided into two groups(acarbose group and metfomfin group)．Acarbose group took acarbose 50～1 00rag，three times per day．Metformin group took metformin 250～500rag，three times per day．The study lasted for 1 2 months．Deteminating FPG、2hPG、TC、TG and HDL before and after the study．Results Both FPG and 2hPG significantly decreased in two groups(P 0．05 and P 0．01)．But 2hPG significantly decreased in acarbose group compaired with that of metfomfin group(P0．0 1)．TC、TG significantly decreased and HDL significantly increased in two groups，but there were no significant difference in two group．Metfomlin group can significantly decreased BMI compaired with acarbose group(P 0．05)．Conclusion Acarbose and metformin can be used to treat IGT patients． KEY WORDS Acarbose；Metfomfin；hnpaired glucose tolerance； 糖耐量减低(impaired glu