骶神经电刺激与辣椒辣素类似物联合治疗特发性女性膀胱过度活动症.pdfVIP

· 1770· 中国基层医药2007年11月第14卷第11期 Chin J Prim Med Pharm．November 2007，v01．14，No．11 骶神经电刺激与辣椒辣素类似物联合治疗 特发性女性膀胱过度活动症 唐 华 廖小七 饶顺琴 黄建成 黄 宏 黄世勇 陈 剑 【摘要】 目的 分析骶神经电刺激与辣椒辣素类似物(RTX)联合治疗女性特发性膀胱过度活动症 (IOAB)的疗效。方法 将32例女性IOAB患者采用经皮穿刺电刺激骶 3神经及100 nmol／L RTX溶液 100 ml膀胱灌注治疗3个月，观察治疗前后排尿日记及尿动力学参数，并通过治疗前后抑郁与焦虑的心理评分来 分析患者的生活质量有无改善。结果 治疗前后排尿日记及尿动力学参数比较，差异有统计学意义(P O．O1)。比较治疗前后抑郁与焦虑的心理评分差异有统计学意义(P0．01)。结论 骶神经电刺激与辣椒辣 素类似物(RTx)联合治疗可改善女性 IOAB患者的排尿功能障碍，可明显改善生活质量。 【关键词】膀胱疾病；脊神经；辣椒辣素；女(雌)性 Analysis of electric sacral neuromdulation and resiniferatoxin in treatment of primary female overactive bladder TANG Hua，LIAO Xiao-qi，RAO Shun—qin，HUANG Jian—cheng，HUANG Hong，HUANG Shi—yong，CHEN Jian．Department of Urology，Second Hospital ofSanming，Yongan，Fujian 366000，China 【Abstract】Objective To analyze the efficacy of electric sacral neuromdulation and resiniferatoxin in patients with female overactive bladder．Methods 32 cases with IOAB female patients accepted percutaneous test sitmulation of the electric sacral nerves at S3．and treated by intravesical instillation with 100ml of 100nmol／L RTX．The effica— cy of voiding status were evaluated．The improvement of female patients life were evaluated comparing the rating of depression and anxiety．Results There were significant improvements in 32 cases in variables included the number of voiding，volume voided and signs every day and urgent uresis．In the rating of depression and anxiety，the patients improved a litter and still had stimulating symptom in urethra and bladder Conclusion The treatment of IOAB with single administratoon of electric sacral neuromdulation and resiniferatoxin is effective，and can successfully im— prove the symptom with little side effects 【Key words】 Bladder diseases；Spinal nevers；Ca~aicin；Female 膀胱过度活动症(0AB)是由尿频、尿急、急迫性 程半年以上的特发型和有明确病因的继发型，我们在 尿失禁等症状组成的症状群，可分为无明确病因、病 诊疗过程中发现特发型膀胱过度活动症(IOAB)以女