黄芩提取物对糖尿病小鼠脂代谢和抗氧化作用的影响.pdfVIP

辽夸压学院学揠v2oo7 o cI． J Li ，28(5) aoning Med Universit v一…g Med ～ ， 黄芩提取物对糖尿病小鼠脂代谢和抗氧化作用的影响 王胜男，徐源梅，李红玉 (辽宁医学院药学院，辽宁锦州121000) 【摘要】 目的 观察黄芩提取物对STZ糖尿病小鼠脂代谢的调节作用和抗氧化保护作用的影响。方法 取80只健 康的昆明小白鼠，随机挑选9只作为正常对照组，对其余小鼠复制糖尿病模型。将造模成功的小鼠分为4组：模型对照组、 黄芩提取物低剂量给药组、中剂量给药组和高剂量给药组，每组9只。按剂量分组给药。30d后观察黄芩提取物对糖尿病 小鼠血脂、肝组织SOD活性、MDA含量、GSH—PX活性的影响。检测血清中TC、TG、HDL—C、LDL—C水平及肝组织 SOD活性、MDA含量、GSH—PX活性。结果 黄芩提取物可显著降低血清TG水平(P0．01或P0．05)；可一定程度的 提高HDC—L水平，降低LDL—C水平，但无显著性；可显著提高糖尿病小鼠肝组织SOD和GSH—PX活性 (P0．05)， 显著降低MDA含量 (P0．01)。结论 黄芩提取物对STZ诱导的糖尿病小鼠脂代谢紊乱具有调节作用；对肝脏的氧化损 伤具有保护作用。 【关键词】 黄芩；糖尿病；血脂 【中图分类号】 R285，5 【文献标识码】 A 【文章编号】 1000—5161(2007)05—0029—03 The Influence of Huangqin Exactive on Lipid Metabolism and Anti0xidati0n in Diabetic Mice WANG Sheng—nan，XU Yuan—mei，LI Hong—yu (Liaoning Medical University，Jinzhou 121000 China) 【Abstract】 Objective TO observe the regulative effect of lipid metabolism and the protective effect of huangqin exactive on mice of STZ induced diabetes． Methods Totally 80 mice were selected and were divided into 2 groups：9 as normal control group and the rest as model group，Then the successful diabetic models were divided into 4 groups：control group，low—dosage，middle— dosage and high—dosage treatment groups with 9 in each group，After 30 days treatment，blood lipid level and SOD activity，MDA content，GSH—PX activity were detected． Results TG level in high—dosage group and middle dosage group were significant low— er than that in model control group(P0．01，P0．05)．High—dosage treatment degraded the LDL—C level and elevated the HDL — C level in some extent．But that Was not notable．Level of SOD and GSH—PX was higher in high—dosage group than that in model control group(P0．05)．Content of MDA in high—dosage group and midd