肿瘤患者外周血活化血小板测定及其临床意义.pdfVIP

一 51 0一 重庆医科大学学报2008年第33卷第4期 (Joumal of Chongqing Medical University 2008．Vo1．33 No．4) 懈瘩暇 文章编号：0253—3626(2008)04—05l0—03 肿瘤患者外周血活化血小板测定及其临床意义 郭金英，，陈 彦z，文阳安，，姜习新-，刘靳波 ，涂植光 (1．重庆医科大学医学检验系 临床检验诊断学省部共建教育部重点实验室、重庆市重点实验室，重庆 400016； 2．西南大学医院检验科，重庆 400715) 【摘 要】目的：比较不同疾病状态下活化血小板测定值的差别及使用阿司匹林防治血栓的效果。方法：采用流式细胞仪测定 126例肿瘤患者和6O例非肿瘤患者外周血活化血小板CD62p和CD63的表达量，以及服用阿司匹林后的变化。 结果：肿瘤患 者外周血的活化血小板CD62p和CD63的表达量明显高于非肿瘤患者( O．05)，有血栓形成的肿瘤患者外周血的活化血小板 CD62p和CD63的表达量明显高于无血栓形成的肿瘤患者(PO．05)，有血栓的肿瘤患者的活化血小板经过阿司匹林干预治疗 后明显下降( ：O．05)。结论：测定活化血小板可以预测肿瘤患者存在高凝状态风险性的大小。同时，服用小剂量肠溶阿司匹林 可以降低外周血活化血小板CD62p和CD63的值。 【关键词】活化血小板(CD62P和CD63)；阿司匹林；恶性肿瘤；血栓 【中国图书分类及分类号】R730．49 【文献标识码】B 【收稿日期12007—09—20 Measurement of activated blood platelets in peripheral blood of tumor patients and its clinical significance G D J／n-ying，et al (The Key Laboratory of Laboratory Medical Diagnostics，Ministry of Education； Department of Medical Laboratory，Chongqing Medical University) 【Abstract】Objective：To compare the measures of activated blood platelets in different disease conditions and the effects of aspirin on blood clots．Methods：The expression of activated platelet CK62p and CD63 and its changing after taking aspirin in 126 tumor patients and 60 non—tumor patients was detected with flow cytometry．Result：The expression of activated platelet CK62p and CD63 in tumor patients was significantly higher than that in non—tumor patients(PO．05)．The expression of activated platelet CK62p and CD63 in tumor patients with clots was significantly higher than that in tumor patients without clots(PO．05)．and the expression of activated platelet CK62p and CD63 decrease significantly after aspirin therapy(P0．05)． Conclusion：The measurement of activated platelet can predict the risk of blood bolts，and taking small