深度烧伤痂皮处理方法及其研究进展.pdfVIP

8年第20卷第2期 The Chinese Journal of Bums Wounds＆Sudace UMem 2008．V01．20．No．2 · 综 述 · 深度烧伤痂皮处理方法及其研究进展 尚新志。唐乾利 【摘要】烧伤创面痂皮的正确处理是治疗烧伤的关键，该文回顾近25年来的国内外文献，对深度烧伤创面 痂皮的处理方法及研究进展做一综述，比较分析了各种痂皮处理方法的优缺点，就目前国内外对痂皮处理方法 进行客观的评价。最后提出了在烧伤湿性医疗技术正规治疗的基础上，同时进行痂下注射MEBO的新技术设想， 其目的是使痂下组织尽早接受MEBO的治疗，痂下发挥MEBO的水解、酶解、皂化、酸败、脂化、酯化六大生 物化学反应，促使坏死组织痂下痂外一起液化，尽快脱落；而且在痂下发挥MEBO原位再生作用，使潜能细胞 转变成皮肤干细胞，干细胞进一步增殖分化形成皮肤组织，达到创面生理性修复之目的。 【关键词】 深度烧伤，痂皮处理方法，综述，研究展望 【中图分类号】R644【文献标识码】A【文章编号】1001—0726(2008)02—0097—04 Eschar Treatment and Its Research Progress in Deep Burns．SHANG Xin—zhi。TANG Qian—li．Guangxi Traditional Chinese Medical College，Nanning City，Guangxi Province，530001，China 【Abstract】 It is a key issue to treat eschar correctly in bums therapy．Both domestic and international literatures about this topic in latest 25 years were reviewed in this article．Therapy and research progress to treat eschar in deep bums were reviewed．Both advantages and disadvantages of various methods in treating eschar was discussed，compared and eval— uated objectively．On the basis of MEBT，a new technique hypothesis of injecting MEBO under the eschar was proposed to have 6 biochemical reactions available，such as hydrolysis，enzymolysis，saponification，rancidify，lipofication，esterifica— lion of MEBO with necrotic tissue of the eschar，then to realize liquefaction and quick defluxion of necrotic tissues．This fi— nally to play a role of regenerative action of MEBO in situ to tum potential regenerative ceils into skin stem cells that would further proliferate and differentiate to form skin tissues，reaching the goal of physiologically repairing wounds． 【Key words】 Deep bums；Eschar treatment；Review；Research prospect 烧伤是外科常见病，在我国其发病率百万人中 烧伤创面痂皮处理方法及研究进展做一综述。 约500o人～10000人 。从发生烧伤至创面愈合， 在整个治疗过程中都存在着创面处理问题。而烧伤 一