稳定型冠心病合并高同型半胱氨酸血症人群冠脉病变特点分析.docVIP

稳定型冠心病合并高同型半胱氨酸血症人群冠脉病变特点分析 Characteristics of Coronary Artery Disease in the Patients with Stable Coronary Heart Disease and Hyperhomocysteinemia 朱桂平，林忠伟，韩彬，张莉，曾智桓，张卫，雷达 作者单位：510080 广东省广州市 广东药学院附属第一医院心内科 通作者：林忠伟，2976325165@ 【摘要】目的 研究稳定型冠心病合并高同型半胱氨酸血症（Hcy）人群冠脉病变特点。方法 选择2013年1月至2014年1月我院经冠状动脉造影确诊且除外急性冠脉综合征的稳定型冠心病（SCAD）患者103例，其中男性68例，女性38例，依据血浆Hcy水平分为高Hcy组、正常Hcy组。两组性别、年龄、血压、血脂等临床基础情况未见统计学差异，具有可比性，将冠脉造影图像采用直径法分析血管狭窄程度，以血管支数法和Gensis评分评价冠脉病变程度。结果 与正常Hcy组相比，高Hcy组在冠脉病变血管支数和Gensis评分方面均存在差异，表现为高Hcy组冠脉三支血管病变比例增高（34.48% vs 8.33%）、Gensis评分增高（37.82±8.29 vs 30.06±4.94）, P＜0.05，差异有统计学意义。且Hcy水平与冠脉病变血管支数、Gensis评分存在正相关关系（P＜0.05）。结论 在稳定型冠心病患者，高血浆Hcy可进一步影响冠脉病变的范围和严重程度。 【关键词】高同型半胱氨酸血症；稳定型冠心病 Characteristics of Coronary Artery Disease in the Patients with Stable Coronary Heart Disease and Hyperhomocysteinemia Zhu Gui-ping，，Han Bin， The First Affiliated Hospital of Guangdong Pharmaceutical University ，Department?of?Cardiology, Guangzhou510080，China [Abstrac] Objectives To investigate characteristics of coronary artery disease in the patients with stable coronary heart disease and hyperhomocysteinemia (Hcy).Methods Choose between January 2013 and January 2013 in our except by coronary artery angiography diagnosis and acute coronary syndrome patients with stable coronary heart disease (SCAD) 103 cases, 68 cases for men and 38 cases for women. According to the level of blood Hcy: the high Hcy group (n = 55) versus the normal Hcy group (n = 48).The baseline of the clinical conditions such as gender, age, blood pressure and lipids was comparable in the two groups. According to coronary angiographic images, the levels of coronary stenosis were analyzed by diameter analysis and the severity of coronary artery diseases was evaluated by the method of vascular count and Gensis score. Results The high Hcy group showed significantly increase in the branches of coronary lesion and Gensis score. The ratio of three branches of coronary lesions and Gensis score were higher in high Hcy group than t