高血压脑出血患者血浆纤维蛋白原和C反应蛋白的水平变化及其意义.pdfVIP

2008年7月第5卷第7期WorldHealthDigest ·临床论著 高血压脑出血患者血浆纤维蛋白原和C反应 蛋白的水平变化及其意义 贾 婕 (河北省张家口市第一医院 075000) [摘要]目的 研究脑出血患者急性期血浆纤维蛋白原 (FIB)和C反应蛋白(CRP)水平的变化，探究其与脑出血的关系，为 临床提供新的诊治依据。方法 38例急 脑出血患者为高血压合并出血性卒中组，另外33例患者为单纯高血压病作为对照， 检测急性期血浆FIB和CRP水平。结果 与对照组相比，高血压合并脑出血患者FIB和CRP水平明显升高(P0．01)，且 FIB 和CRP浓度明显升高者，并发症多，预后差。结论 炎症反应可能是出血性卒中患者急性期神经元损伤的原因之一，C 反应蛋白和纤维蛋白原浓度的水平变化与病情预后有一定的关系。 关键词： 高血压脑出血 纤维蛋白原 C反应蛋白。 The Changes and Re1atiOnship of C—reative protein and Fibrinogen concentration in Patients with Hypertensive Intracerebra1 Hemorrhage JiaJie HeBeiShengZhangJiaKouShiDiYiYiYuanNeiSanKe(075000) [Abstract]objective：To study the changes and yelationships of Creative protein(CRP)and fibrinogen cOncentratiOns in patients with intracerebra1 hemorrhage．Methods：Fift—eight essential Hypertensive patients with intracerebra1 hemorrhage were a group， other thirt—three essential Hypertensive patients act as contro1． For al 1 patients， the concentrations of CRP and fibrinogen were measured．Resul ts：CRP and fibrinogen concentrations increased significantly alSO(pO．O1)in intracerebral hemorrhage group comparing to the simple essential Hypertensive group．The patients with higher CRP and fibrinogen cOncentratiOns had more complications and worse prognosiS．Conclusion：Inflanmatory reaction may be one of the causes of neuron injury in patients with intracerebral hemorrhage，The changes of CRP and fibrinogen concentrations in patients with intracerebral hemorrhage are related with． [|【ey words]hypertensive’intracerebral hemorrhage：C-reactive protein~fibrinogen． 中图分类号：R544．1 、 文献标识码：B 文章编号：1672-5085(2008)7-0509-02 1对象和方法 国IMMULITEIO00全自动化学发放仪检测@FIB测定：采用美 1．1对象