鬼箭羽钩藤复方液对心肌肥大大鼠L型钙电流的影响.pdfVIP

蠢蓬盈 (M cal J叫mal 0f Chinese Pe0ple，s Anlle(1 P0lice F es)v01．19№．07 2008—07出版 6ll 鬼箭羽钩藤复方液对心肌肥大大鼠L型钙电流的影响 王佐好 李海英 韩晨光 赵 娟 佟长青 (武警医学院： 生理学与病理生理学教研室； 附属医院 医教部，天津300l62) 【摘 要】 目的 探讨鬼箭羽钩藤复方液对高血压性心肌肥大的影响。方法 利用腹主动脉缩窄法建立高血压性心肌 肥大模型，利用灌胃法给予中药治疗，采用离体大鼠心脏Langendorff灌注法急性分离心肌细胞，利用膜片钳全细胞技术记录L 型钙电流，比较正常对照组、高血压模型组及中药治疗组之间的区别。结果 高血压模型组的L型钙电流密度显著高于正常 对照组(P0．05)；中药治疗组的L型钙电流密度显著小于高血压模型组(P0．05)，与正常对照组相比无显著性差异(P 0．o5)。结论 鬼箭羽钩藤复方液具有逆转高血压性心肌肥大的作用。 【关键词】鬼箭羽钩藤复方液 高血压痛 心肌肥大 L型钙电流 【中国图书分类号】R541．3 Effect of compound Evonymus alata and Uncaria rhynchophylla decoction on L--type calcium channels in rats with cardiac hypertrophy WANG Zuoyu，LI Haiying，HAN Chenguang，ZHAO Juan，and TONG Changqing．Department of Physiology，Medical College of Chinese People’S Armed Police Forces，Ti in 300162，China 【Abstract】Objective To study the effect of comypound Evonymus alata and Uncaria rhynchophylla decoction on cardiac hypertro— phy induced by hypertension in rats．Methods Cardiac hypertrophyrat model was developed by par~al hgation of abdominal aorta．The decoc— tion was given intragastrically．Langendorff system was used to separate myocardiac cells．Whole—cell patch clamp recording technique was used to record the current of L—type calcium channels in control group，hypertension group and herbal medicine group．Results The current density ofL—type calcium channels in control group was higher than that in hypertension group(P0．05)，whereas that in herbal medicine group was lower than that in hypertension group(P0．05)．There was no significant difference between control group and herbal medicine group(PO．05)．Conclusions Compound Evonymus alata and Uncaria ，z 叩 decoction can reverse cardiac hypertrophy induced by hypertension． 【Key words】 Evonyrma~alata Uncaria rhyrwhophylla Hypertension Cardiac hypertrophy L—type calcium currents 心肌肥大是高血压病心脏代偿的结果，也是病 院实验动物研究所提供)随机分为正常对照组、高血 情进一步发展的危险因素，故逆转心肌肥大成为中