血清维生素A及儿童1型糖尿病相关性探析.docVIP

血清维生素A及儿童1型糖尿病相关性探析【摘要】 目的 初步探讨血清维生素A水平与儿童1型糖尿病(T1DM)关系，了解糖化血红蛋白(HbA1c)、血清空腹C-肽与血清维生素A的相关性。方法 选取32例T1DM患儿为T1DM组，28例健康体检儿童为对照组，用微量荧光方法检测两组血清维生素A水平，用化学发光法、激光散射比浊法分别测定32例T1DM患儿血清C-肽、HbA1c。结果 T1DM组血清维生素A水平明显低于对照组(P0.01)；T1DM组血清维生素A水平与空腹血清C-肽水平呈正相关(r=0.356, P0.05)，与HbA1c呈负相关(r=-0.394, P0.05)。结论 T1DM患儿体内存在维生素A缺乏，维生素A水平低下可能与T1DM的发生有关。? 【关键词】 维生素A；糖尿病；1型；儿童 ?? The relationship between serum concentration of vitamin A and type 1 diabetes mellitus in children CHEN Yong-xing, WEI Hai-yan, LI Chun-zhi, et al. Department of Endocrinology of Zhengzhou Childern?s Hospital, Zhengzhou 450052,China ? 【Abstract】 Objective To explore the relationship between serum concentration of vitamin A and type 1 diabetes mellitus in children. Methods Totally 32 children with T1DM were taken as T1DM group, and 28 healthy children as normal control group. The serum concentration of vitamin A was determined by the method of micro-flourescence, and the serum level of C-peptide and the level of HbA1c were determined by the methods of chemoluminescence and laser nephelometry， respectively. Results The level of vitamin A in T1DM group was lower than that in control group(P0.01). The serum concentration of vitamin A was positively correlated with the serum level of C-peptide in T1DM group(r=0.356, P0.05), and negatively with the level of HbA1c(r=-0.394, P0.05).Conclusion The deficiency of vitamin A is present in T1DM, and there is maybe relationship between the low serum level of vitamin A and the development of type 1 diabetes mellitus in children.? 【Key words】 Vitamin A; Diabetes mellitus; Type 1; Child ? 维生素A(vitamin A)是儿童时期最重要的微量营养素之一，研究证实维生素A对免疫系统具有调节作用，可通过多种机制调节各种自身免疫性疾病，纠正免疫失衡［1,2］。1型糖尿病(Type 1 diabetes mellitus，T1DM)是由T细胞介导的器官特异性自身免疫疾病［3］，因此，维生素A在T1DM发病机制中的作用越来越来受到学者们的关注。本文通过对2008年3月至2010年1月于我院就诊的32例新发T1DM患儿的血清维生素A水平检测，并分析其与HbA1c、空腹C-肽的相关性，初步探讨血清维生素A与儿童T1DM发病的关系。? 1 资料与方法? 1.1 一般资料 试验血样均来自我院内分泌科住院的新发T1DM患儿(病程3月)及同期于儿童保健科健康体检的儿童。T1DM组：32例，其中男18例，女14例，年龄