奥美拉唑联合莫沙必利治疗胆汁反流性胃炎疗效观察.doc

奥美拉唑联合莫沙必利治疗胆汁反流性胃炎疗效观察[摘要] 目的：探讨奥美拉唑联合莫沙必利治疗胆汁反流性胃炎的疗效。方法：回顾性分析使用奥美拉唑联合莫沙必利治疗的52例胆汁反流性胃炎患者的临床资料，观察治疗效果及不良反应。结果：本组52例患者治疗后均取得满意疗效，其中痊愈46例（88.46%），好转6例（11.54%），总有效率为100.00%。51例患者2例出现腹泻，1例出现腹痛，均未给予特殊处理，1周内消失，全部患者治疗期间血尿常规和肝肾功能均无异常。结论：奥美拉唑联合莫沙必利可有效缓解胆汁反流性胃炎症状，是治疗反流性胃炎的有效药物，值得临床推广。 [关键词] 反流胆汁；胃炎；疗效观察；奥美拉唑；莫沙必利 [中图分类号] R975[文献标识码]B [文章编号]1674-4721（2011）07（c）-089-02 Clinical observation of omeprazole joint mosapride in treatment of bile reflux gastritis JIANG Ping Department of Medicine, Banfu Hospital of Zhongshan City, Guangdong Province, Zhongshan 528459, China [Abstract] Objective: To explore the clinical effect of omeprazole joint mosapride in treatment of bile reflux gastritis. Methods: Clinical datas of 52 cases with bile reflux gastritis treated with omeprazole joint mosapride were analyzed retrospectively, observed the effect and adverse reactions. Results: 52 patients had achieved satisfactory curative effect after treatment, 46 cases (88.46%) of recovery, 6 cases (11.54%) of improvement. Total effective rate was 100.00%. Of 51 cases, 2 patients suffered diarrhoea, abdominal pain in 1 case, all did not give special treatment, that disappeared in 1 week, all patients, blood routine urine routine and hepatic and renal function all without exception during treatment. Conclusion: Omeprazole joint mosapride can relieve bile reflux gastritis symptom effectively, it is effective drugs of the treatment of reflux gastritis, it is worth of clinical promotion. [Key words] Reflux bile; Gastritis; Observation of curative effect; Omeprazole; Mosapride 胆汁反流性胃炎是消化系统常见的疾病。反流胆汁可破坏胃黏膜屏障，导致胃腔内的胃酸（H+）重新反渗入胃壁，引起自身消化、胃黏膜炎症乃至溃疡。目前治疗以抑酸及促动力药物治疗为主。本科采用奥美拉唑联合莫沙必利治疗胆汁反流性胃炎取得较为满意的疗效，现总结报道如下： 1 资料与方法 1.1 一般资料 本组所选52例为本院2009年2月~2011年2月就诊患者，均有腹痛或上腹饱胀不适，胃脘部烧灼感，反酸，恶心，呕吐胆汁等症状，其中，男30例，女22例，年龄18~62岁，平均38岁，病程6~24个月。所有患者均无胃部手术史，无其他系统疾病，且均经肝功能，B超胃镜检查，排除肝胆疾病及消化性溃疡。病理改变是黏膜下层水肿，黏膜层血管扩张，充血，炎症细胞浸润。胃镜证实为胃液内有胆汁潴留及胃窦明显炎症，符合胆汁反流性胃炎内镜诊断标准。 1.2 方法 患者均给予一般治疗，如戒烟戒酒，低脂饮食，少摄取糖类物