超敏CRP检测在新生儿败血症中临床意义.docVIP

超敏CRP检测在新生儿败血症中临床意义【摘要】 目的 探讨超敏CRP(hsCRP)检测在新生儿败血症中的临床意义。方法 2009年7月至2011年7月我院NICU收治的临床诊断新生儿败血症的78例患儿作为观察组，入院时和恢复期检测静脉血hsCRP,并与对照组(60例正常新生儿)作比较。结果 观察组疾病初期血hsCRP及其阳性率明显高于对照组，恢复期hsCRP降至正常或接近正常，比较差异有统计学意义(P005)。结论 hsCRP检测对新生儿败血症的诊断和疗效监测有重要意义，特异性和敏感性高，结果准确可靠，值得推广。 【关键词】 超敏C反应蛋白;新生儿;败血症 Clinical significance of high sensitivity C reactive protein in neonatal septicemia CHEN Jun, CHEN Jian, Maoming Municipal Maternity and Infant Health Institute,Maoming 525000,China 【Abstract】 Objective To explore the clinical significance of high sensitivity C reactive protein(hsCRP) in neonatal septicemia Methods 78 cases with neonatal septicemia who were diagnosed by clinical data were internalized into observation group and detected hsCRP on admission and in recovery stage,and 60 normal neonates were simultaneous detected as control group Results Before treatment,the hsCRP level of observation group was significantly higher than the control group,and descented to normal level in recovery stageThe difference was significant(P005)Conclusion The detection of hsCRP is significant for diagnosis and curative effect monitoring of neonatal septicemiaIt is specific, susceptive and veraciousAnd it is worth spreading. 【Key words】 High Sensitivity C reactive protein;Neonatal; Septicemia 新生儿败血症是指新生儿期细菌或真菌侵入血循环并在其中生长繁殖，产生毒素所造成的全身性感染。其发生率占活产婴的1‰~8‰。出生体重越轻，发病率越高，VLBW可高达164‰，长期住院者可高达300‰［1］。该病病情凶险，诊断治疗不及时死亡率高。然而其临床表现不典型，细菌培养等“金标准”耗时长，给早期诊断带来困难。CRP是由肝脏合成的急相反应蛋白，在炎症、应急过程时升高，疾病缓解后迅 -------------------------------------------------------------------------------- 作者单位：525000 广东省茂名市妇幼保健院新生儿科 速恢复正常［2］。近年来发展的hsCRP把CRP的检测下限降至015 mg/L，有利于新生儿败血症的早期诊断和疗效监测。本文对78例临床诊断新生儿败血症的患儿进行hsCRP检测，现报告如下。 1 资料与方法 11 一般资料 2009年7月至2011年7月我院NICU收治的临床诊断新生儿败血症的78例患儿均符合相关诊断标准［3］：有感染中毒症状(体温不稳定、精神食欲差、哭声减弱、 -------------------------------------------------------------------------------- ［6］ Armstrong EJ， Morrow DA， Sabatine MS Inflammatory biomarkers in acute coronary syndromes part 1I： acutephase rea