小鼠气管异位移植后模拟肺移植慢性排斥反应模型的建立.pdfVIP

中国组织工程研究与临床康复第12 番第5 JfIj 2∞8 - 01 - 29 出版 @支真寰基础医学 Journal of Clinical Rehabilitative nssue Engineering Research Jan阳η29， 2ω8 Vol.12, No.5 小鼠气管异位移植后模拟肺移植慢性排斥反应模型的建立针 王炜1 ，陈放2 ，韩彪\张运曾2 ，魏宁1 粤艺窑茅句蟹植硅哩饵，.，.， -、毛毯 心 ,..~:叽气~.T 如~，a耀缓急 惯路费比叫理搭揭在嘉猎篇费，，_可言 、.~ 至 1喝巨二3江农急君在越雷离翻醺翩翩自回国...绢画捞，飞篇悟到司饵缉捕领唱画_、主荤勒篇，到穗结窑喝棚晒鹏_.盹 Establishment of a mouse model of chronic lung allograft rejection after heterotopic tracheal allografting 2 2 1 Wang Wei\ Chen Chang , Han Biao\ Zhang Yun-ceng , Wei Ning Abstract 1 artment of 问 AIM: Obliterative bronchiolitis (OB) is the most important cause of graft dysfunction following lung transplantation , Time cost Thoracic Surg町y， Fir哑 Hospital of and technique requirement limit the application of animal models of in situ lung 町ansplant in the research ofOB. We establish创a Lanzhou University, new mouse model of chronic allograft rejection after lung 町ansplantation using the improv创 techniques of orthotopic lung Lan才10U 73创lOO， allografl transplantation to provide a novel modeling method for OB research , Gansu Provin阻， METHODS: (The experiment was perform创 in the animal laboratory of Shanghai Pulm侃ary Hc叩ital from July to August China; Depanment 2∞7. Th e experimental proc创ure was acco叫ed with animal ethical requirement. In experimental group , 10 C57BU6 mice serv创 of Thoracic Surgery, Shanghai Pulmonary as donors , and 10 BALB/c as recipients , while in control group , 20 BALB/c mi臼 serv创 as donors and recipien饵， respectively. ② Hospi国1. Sh