bimatoprost effects on aqueous humor dynamics in monkeys在猴子bimatoprost影响房水动力学.pdfVIP

Hindawi Publishing Corporation Journal of Ophthalmology Volume 2010, Article ID 926192, 5 pages doi:10.1155/2010/926192 Research Article Bimatoprost Effects on Aqueous Humor Dynamics in Monkeys David F. Woodward,1 Achim H.-P. Krauss,2 and Siv F. E. Nilsson3 1 Department of Biological Sciences, Allergan, Inc., Irvine, CA 92612, USA 2 Ophthiris, GlaxoSmithKline, King of Prussia, PA, USA 3 Division of Drug Research, Department of Medical and Health Sciences, Faculty of Health Sciences, University of Linkoping, Linkoping, Sweden ¨ ¨ Correspondence should be addressed to David F. Woodward, woodward david@ Received 9 July 2009; Revised 2 December 2009; Accepted 28 February 2010 Academic Editor: Ian Grierson Copyright © 2010 David F. Woodward et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The effects of bimatoprost on aqueous humor dynamics were quantified in monkey eyes. Uveoscleral outflow was measured by the anterior chamber perfusion method, using FITC-dextran. Total outflow facility was determined by the two-level constant pressure method. Aqueous flow was measured with a scanning ocular fluorophotometer. Uveoscleral outflow was 0.96 ± 0.19μL min−1 in vehicle-treated eyes and 1.37 ±0.27 μL min−1 (n = 6; P .05) in eyes that received bimatoprost 0.01% b.i.d. × 5 days. Bimatoprost had no effect on total outflow facility, which was 0.42 ± 0.05 μL min−1 at baseline and 0.42 ± 0.04 μL min−1 after bimatoprost treatment. Bimatoprost had no significant effect on aqueous humor flow. This study demonstrates that bimatoprost increases uveos