cyp2c19 (+ or -)2(+ or -)17 diplotypes prognostic impactson patients with acute coronary syndromecyp2c19(+或-)2(+或-)17 diplotypes预后impactson急性冠脉综合征患者.pdfVIP
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cyp2c19(or-)2(or-)17diplotypesprognosticimpactsonpatientswithacutecoronarysyndromecyp2c19(或-)2(或-)17diplotypes预后impactson急性冠脉综合征患者
World Journal of Cardiovascular Diseases, 2012, 2, 260-268 WJCD
/10.4236/wjcd.2012.24041 Published Online October 2012 (http://www.SciRP.org/journal/wjcd/)
CYP2C19 (+ or −) *2/ (+ or −) *17 Diplotypes: Prognostic
impactson patients with acute coronary syndrome
1,2* 3 1,2 1 4
Rogério Teixeira , Manuela Grazina , Pedro Monteiro , Francisco Soares , Margarida Lourenço ,
Guilherme Pêgo1
1Service of Cardiology, Central Hospital of University of Coimbra, Coimbra, Portugal
2Faculty of Medical University of Coimbra, Coimbra, Portugal
3Laboratory of Biophysical Genetics, Central of Neuroscience and Biologic Celular, Faculty of Medical University of Coimbra,
Coimbra, Portugal
4Service of pathology Clinic, Central hospital of University of Coimbra, Coimbra, Portugal
*
Email: rogeriopteixeira@
Received 23 August 2012; revised 26 September 2012; accepted 6 October 2012
ABSTRACT diplotype was an independent predictor of outcome,
conferring a 5.2-fold higher adjusted risk for the
Purpose: To investigate the prognostic impacts of a
composite endpoint than the others diplotypes. Con-
combined clopidogrel-metabolizing genotypes CYP
clusion: In our study, patients with the intermediate
2C19 (+ or −)*2/(+ or −)*17 on patients with acute
pl
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