cytokines and hcv-related disorders细胞因子和与丙肝障碍.pdfVIP

Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2012, Article ID 468107, 10 pages doi:10.1155/2012/468107 Review Article Cytokines and HCV-Related Disorders Poupak Fallahi,1 Clodoveo Ferri,2 Silvia Martina Ferrari,1 Alda Corrado,1 Domenico Sansonno,3 and Alessandro Antonelli1 1 Department of Internal Medicine, School of Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy 2 Department of Internal Medicine, Rheumatology Unit, School of Medicine, University of Modena and Reggio Emilia, Via del Pozzo, 71, 41100 Modena, Italy 3 Department of Internal Medicine and Clinical Oncology, University of Bari, Piazza Giulio Cesare, 11, 70124 Bari, Italy Correspondence should be addressed to Alessandro Antonelli, alessandro.antonelli@med.unipi.it Received 5 January 2012; Accepted 17 February 2012 ¨ Academic Editor: Jurg Schifferli Copyright © 2012 Poupak Fallahi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cytokines are intercellular mediators involved in viral control and liver damage being induced by infection with hepatitis C virus (HCV). The complex cytokine network operating during initial infection allows a coordinated, effective development of both innate and adaptive immune responses. However, HCV interferes with cytokines at various levels and escapes immune response by inducing a T-helper (Th)2/T cytotoxic 2 cytokine profile. Inability to control infection leads to the recruitment of inflammatory infiltrates into the liver parenchyma by interferon (IFN)-gamma-inducible CXC chemokine ligand (CXCL)-9, -10, an