cystic fibrosis overview and update on infant care囊胞性纤维症概述和更新对婴儿护理.pdfVIP

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cystic fibrosis overview and update on infant care囊胞性纤维症概述和更新对婴儿护理.pdf

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cystic fibrosis overview and update on infant care囊胞性纤维症概述和更新对婴儿护理

Open Journal of Pediatrics, 2012, 2, 187-196 OJPed /10.4236/ojped.2012.23032 Published Online September 2012 (http://www.SciRP.org/journal/ojped/) * Cystic fibrosis overview and update on infant care # Raj Padman , Vandna Passi Division of Pulmonary Medicine, Nemours/Alfred I. duPont Hospital for Children, Wilmington, USA Email: #rpadman@ Received 9 November 2011; revised 31 January 2012; accepted 16 July 2012 ABSTRACT sweat glands, salivary glands, pancreas, hepatobiliary system, lungs, intestines, and reproductive system. It is Cystic fibrosis is now the most common serious, auto- characterized by the clinical phenotype of recurrent res- somal-recessive disease. It has been described in piratory infections, pancreatic insufficiency, and an ele- every population in all parts of the world. In the US, vated sweat chloride. The major morbidity and mortality newborn screening is available in all states. Current are related to the involvement of the lungs, which appear studies demonstrate that newborn screening, early free of infection at birth but within a few weeks exhibit diagnosis, early nutritional and environmental inter- small airway mucus plugging and