effect of apigenin on the reproductive system in male mice芹黄素对雄性小鼠的生殖系统的影响.pdfVIP

Vol.2, No.5, 435-440 (2010) Health doi:10.4236/health.2010.25065 Effect of apigenin on the reproductive system in male mice Hui Li, Hong-Bo Li, Ming Zhang, Fang Yan, Zhong-Xian Zhang, Zhi-Lan Li* School of Public Health, Lanzhou University, Lanzhou, China; *Corresponding Author: lizhl@ Received 23 November 2009; revised 7 January 2010; accepted 8 January 2010. ABSTRACT first suggested a possible decline in human sperm con- centration [1]. Since then, there has been increased This study aimed to characterize the effect of awareness of the possible effects of chemicals on male apigenin on the reproductive system in male fertility [2,3]. It is of paramount importance to assess mice. Adult male mice were treated with intrap- potential health risks associated with exposure to eritoneal injection of apigenin at the dose levels chemical or physical agents since these agents may in- of 5, 10, 15, 20 and 25 mg/kg.bw, 0.05% DMSO terfere with the ability of individuals to produce normal and 0.9% normal saline daily for seven days. progeny. Apigenin is a common flavone present in diet: Then, testis and epididymis sperms in sperm it is not only in aromatic plants (camomilla, rosemary motility, sperm morphology, the percentages of and parsley), but also in celery, apple, honey, fennel and ploidy cells and seminiferous epithelium cells at wheat germ [4-6]. the cell-circle phase, and the ratio of ploidy cell