原创力文档efficacy and effectiveness of exercise on tender points in adults with fibromyalgia a meta-analysis of randomized controlled trials疗效和运动对温柔点成人纤维肌痛的有效性随机对照试验的荟萃分析.pdfVIP
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efficacy and effectiveness of exercise on tender points in adults with fibromyalgia a meta-analysis of randomized controlled trials疗效和运动对温柔点成人纤维肌痛的有效性随机对照试验的荟萃分析
Hindawi Publishing Corporation
Arthritis
Volume 2011, Article ID 125485, 10 pages
doi:10.1155/2011/125485
Research Article
Efficacy and Effectiveness of Exercise on Tender Points in
Adults with Fibromyalgia: A Meta-Analysis of Randomized
Controlled Trials
George A. Kelley,1 Kristi S. Kelley,1 and Dina L. Jones2
1 Meta-Analytic Research Group, Robert C. Byrd Health Sciences Center, Department of Community Medicine, School of Medicine,
West Virginia University, P.O. Box 9190, Morgantown, WV 26506-9190, USA
2 Department of Orthopaedics and Division of Physical Therapy, West Virginia University, Morgantown, WV 26506-9196, USA
Correspondence should be addressed to George A. Kelley, gkelley@
Received 14 June 2011; Accepted 12 July 2011
Academic Editor: Shinichi Kawai
Copyright © 2011 George A. Kelley et al. This is an open access article distributed under the Creative Commons Attribution
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly
cited.
Fibromyalgia is a major public health problem affecting an estimated 200 to 400 million people worldwide. The purpose of
this study was to use the meta-analytic approach to determine the efficacy and effectiveness of randomized controlled exercise
intervention trials (aerobic, strength training, or both) on tender points (TPs) in adults with fibromyalgia. Using random effects
models and 95% confidence intervals (CI), a statistically significant reduction in TPs was observed based on per-protocol analyses
(8 studies representing 322 participants) but not intention-to-treat analyses (5 studies representing 338 participants) (per-protocol,
g , −0.68, 95% CI, −1.16, −0.20; intention-to-treat, g , −0.24, 95% CI, −0.62, 0.15). Changes were equiva
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