超声造影在评估肝炎肝纤维化及肝硬化中应用价值.docVIP

超声造影在评估肝炎肝纤维化及肝硬化中应用价值【摘要】 目的 利用声诺维（SonoVue）造影剂来评估超声造影在肝炎肝纤维化及肝硬化中的临床价值。方?法 ?选取慢性肝炎患者40例，分为肝纤维化组30例，肝硬化组10例，均经超声引导下肝组织活检病理证实；对照组10例，来自健康的自愿者。在造影模式下，经肘静脉注射超声造影剂SonoVue，记录造影剂到达肝动脉时间、到达门静脉时间、到达肝静脉时间及肝实质增强峰值时间。结果 肝纤维化组超声造影剂到达肝静脉显影时间较对照组延长，差异无统计学意义，时间分别为（25.52±4.35） s、（21.40±4.87） s；肝硬化组超声造影剂到达肝静脉显影时间较肝纤维化组、对照组缩短，差异有统计学意义，时间分别为（16.45±2.86） s、（25.52±4.35） s、（21.40±4.87） s；肝纤维化组、肝硬化组的肝实质增强峰值时间较对照组延长，差异有统计学意义，时间分别为（43.53±8.63） s、（56.78±11.56） s、（28.45±8.32） s。超声造影剂到达肝肝动脉、门静脉显影时间在3组之间差异无统计学意义。结论 超声造影技术在评估肝炎肝纤维化及肝硬化的诊断中有一定的临床价值，可以更好的指导临床治疗。? 【关键词】 超声造影； 肝纤维化； 肝硬化； 声诺维?? The value of Contrast-enhanced ultrasound in the evaluation of the hepatitis and cirrhosis of the liver fibrosis clinical ?WANG Gang, LIU Jian. Medical Imaging Key Laboratory of Sichuan Province, North Sichuan Medical College, Nan Chong 637007, China?? 【Abstract】 Objective To investigate the application value of contrast-enhanced sonography in the hepatitis and cirrhosis of the liver fibrosis.Methods Select chronic hepatitis patients group of 30 cases of liver fibrosis and 10 cases of liver cirrhosis group. All the cases in both the groups were pathologically confirmed by liver tissue biopsy guided by ultrasound. There were 10 cases in the control group of healthy volunteers. Contrast pulse sequencing(CPS) technique was used. The arrival time of hepatic artery, the arrival of portal vein, the arrival of hepatic vein time and the enhanced peak time of liver parenchyma were recorded.Results In liver fibrosis group, the arrival time of hepatic vein(25.52±4.35) s was extended. The arrival time of the control group was (21.40±4.87) s. But there was not significant difference between the two groups The arrival time(16.45±2.86) s of hepatic vein in cirrhosis group was shorter than that of the liver fibrosis group(25.52±4.35) s and the control group(21.40±4.87) s. There was a statistically significant difference among them. The enhance peak of time of the liver parenchyma in liver fibrosis group and liver cir