selective internal radiation therapy for gastrointestinal neuroendocrine tumour liver metastases a new and effective modality for treatment选择性内部放射治疗胃肠道神经内分泌肿瘤肝转移一个新的、有效的治疗方式.pdfVIP

SAGE-Hindawi Access to Research International Journal of Hepatology Volume 2011, Article ID 404916, 7 pages doi:10.4061/2011/404916 Clinical Study Selective Internal Radiation Therapy for Gastrointestinal Neuroendocrine Tumour Liver Metastases: A New and Effective Modality for Treatment Harshal Rajekar, Kashan Bogammana, and Richard S. Stubbs Wakefield Gastroenterology Centre and University of Otago, Private Bag 7909, Wellington 6242, New Zealand Correspondence should be addressed to Richard S. Stubbs, rsstubbs@wakefieldclinic.co.nz Received 15 June 2011; Revised 3 September 2011; Accepted 3 September 2011 Academic Editor: Dan Granberg Copyright © 2011 Harshal Rajekar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. Nonresectable neuroendocrine tumour (NET) liver metastases respond poorly to most widely available and used therapies. Selective Internal Radiation Therapy (SIRT) is becoming recognized as a new modality for selectively treating non- resectable liver tumours. This paper presents an experience of 14 patients with non-resectable NET liver metastases treated with SIRT. Methods. Between September 1997 and October 2009 14 patients with extensive NET liver metastases were treated with 2.0 to 3.0 GBq of 90Yttrium microspheres. Repeat SIRT was undertaken in three patients after 16, 27, and 48 months, respectively. Responses were assessed clinically, biochemically, and with serial CT scans. Survival was measured from initial SIRT. Results. Some response was seen in all 14 patients. Carcinoid syndrome improved or resolved in 10/10 instances. 24-hour urinary 5-HIAA or serum chr