the dynamics of germinal centre selection as measured by graph-theoretical analysis of mutational lineage trees生发中心的动态选择以图形理论分析突变谱系树.pdfVIP

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the dynamics of germinal centre selection as measured by graph-theoretical analysis of mutational lineage trees生发中心的动态选择以图形理论分析突变谱系树.pdf

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the dynamics of germinal centre selection as measured by graph-theoretical analysis of mutational lineage trees生发中心的动态选择以图形理论分析突变谱系树

Developmental Immunology, December 2002 Vol. 9 (4), pp. 233–243 The Dynamics of Germinal Centre Selection as Measured by Graph-Theoretical Analysis of Mutational Lineage Trees* a,† b c a c DEBORAH K. DUNN-WALTERS , ALEX BELELOVSKY , HANNA EDELMAN , MONICA BANERJEE and RAMIT MEHR aDepartments of Immunobiology and Histopathology, GKT Medical School, London, UK; bDepartment of Mathematics and Computer Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel; cFaculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel We have developed a rigorous graph-theoretical algorithm for quantifying the shape properties of mutational lineage trees. We show that information about the dynamics of hypermutation and antigen- driven clonal selection during the humoral immune response is contained in the shape of mutational lineage trees deduced from the responding clones. Age and tissue related differences in the selection process can be studied using this method. Thus, tree shape analysis can be used as a means of elucidating humoral immune response dynamics in various situations. Keywords: B lymphocytes; Somatic hypermutation; Germinal centre; Antibodies INTRODUCTION mathematical models exploring the dynamical inter- actions between somatic hypermutation and clonal Memory B lymphocyte generation involves afﬁnity selection (Sulzer et al., 1993; Kepler and Perelson, maturation of the cel