低温时蛙皮素对IL-1β致热大鼠降温作用及及PGE2相关性.docVIP

低温时蛙皮素对IL-1β致热大鼠降温作用及及PGE2相关性[摘要] 目的：探讨4℃时蛙皮素（BN）的降温作用及其机制。方法：在4℃环境下，以IL-1β致热大鼠为研究对象，采用放免法对下丘脑和血浆中前列腺素E2（PGE2）含量进行同步检测。结果：在IL-1β诱导发热大鼠中，下丘脑及血浆中PGE2含量显著升高（P 1.3 体温反应指标及数据处理 体温反应指标用平均体温反应曲线表示，体温变化情况采用TRI3及ΔT表示，所有数据以均数±标准差（x±s）表示，采用两样本均数比较的t检验，P [5]刘利丹,李妍,赵书芬,等.热应激对大鼠TNF-α性发热及下丘脑中cAMP含量的影响[J].中国药理学通报,2005,21(9):1054-1057. [6]张量,苏艳阳,赵书芬,等.蛙皮素对发热大鼠的降温作用及与PGE2的相关性[J].中国药理学通报,2008,24(9):1212-1215. [7]张量,佟雷,赵书芬,等.低温时蛙皮素对IL-1β致热大鼠下丘脑和血浆cAMP含量的影响[J].中国临床药理学与治疗学,2005,10(12):1354-1357. [8]Zhang YH, Yanase-Fujiwara M, Hosono T, et al. Warm and cold signals from the preoptic area: which contribute more to the control of shivering in rats [J]. Physiol,1995,485(Pt 1):195-202. [9]Brown JW, Whitehurst ME, Gordon CJ, et al. The Pre-Optic Anterior Hypothalamus (POAH) partially mediates the hypothermic response to he-morrhage in rats [J]. Brain Res,2005,1041(1):1-10. [10]Ravussin E. The presence and role of brown fat in adult humans [J]. Curr Diab Rep,2010,10(2):90-92. [11]杨惠玲,潘景轩,吴伟康.高级病理生理学[M].2版.北京:科学出版社,2006:102-103. [12]Leon LR. Invited review: cytokine regulation of fever: studies using gene knockout mice [J]. Appl Physiol,2002,92(6):2648-2655. [13]Cao WH, Madden CJ, Morrison SF. Inhibition of brown adipose tissue thermogenesis by neurons in the ventrolateral medulla and in the nucleus tractus solitarius [J]. Physiol Regul Integr Comp Physiol,2010,299(1):277-290. [14]Dinarello CA. Cytokines as endogenous pyrogens [J]. Infect Dis,1999,179(Suppl 2):294-304. （收稿日期：2010-12-17） “本文中所涉及到的图表、公式、注解等请以PDF格式阅读” 1