神经生长因子治疗爆震性耳聋临床观察.docVIP

神经生长因子治疗爆震性耳聋临床观察[摘要] 目的:观察爆震性耳聋患者临床用神经营养因子治疗的效果。方法: 2006年2月～2009年2月我院门诊患者19例(30耳)采用注射用鼠神经生长因子肌内注射10 d,观察注射前后纯音测定听力变化。结果:19例爆震性耳聋患者(30耳)经用神经营养因子注射治疗10 d后,3例早期患者听力有不同程度的恢复。30耳爆震性耳聋经神经营养因子治疗前后纯音测听频率均值比较,有显著性差异(P=0.01)。其治疗后有效率为11%,与文献报道用金钠多治疗有效率89%比较,本组有效率较低。结论:临床用神经生长因子治疗爆震性耳聋对发病早期患者听力恢复有一定的积极效果,宜早期治疗,病程超过1个月者治疗效果差。 [关键词] 神经生长因子;爆震伤;耳聋;听力 [中图分类号] R764.43 [文献标识码]A [文章编号]1673-7210(2010)02(a)-020-02 The clinical observation of nerve growth factor in the treatment of blast exposure hearing damage ZHAI Suoqiang, YU Ning, ZHU Yuhua, QIN He (Institute of Otorhinolaryngology of PLA General Hospital, Beijing 100853, China) [Abstract] Objective: To observe the effect of nerve growth factor on blast exposure hearing damage. Methods: 19 (30 ears) cases of patients suffering from explosion hearing loss were collected in clinic from February 2006 to February 2009. They were injected with mouse nerve growth factor for 10 days, and to observe the pure-tone hearing changes before and after injection. Results: 19 cases of patients (30 ears) were treated for 10 days, there was a significant difference in the hearing threshold before and after treatment. The hearing of 3 cases suffered from short time recovered almost to normal hearing level. The effective rate was 11% after treatment, and it was lower compared with that (89%) of using Jin Naduo treatment. Conclusion: Nerve growth factor has some definite effect in treating early explosion hearing loss. Using it earlier is emphasised in clinical treatment. [Key words] Nerve growth factor; Blast injuries; Deafness; Hearing 爆震性耳聋是一种爆震后造成耳蜗和神经损伤的感音神经性聋,不仅在战时军队人员发病率高,而且平时燃放鞭炮、坑道作业人员和突发爆震事件也可造成听力损伤。但是,爆震性耳聋发病较特殊,关键在预防,一旦造成爆震性耳聋在临床上治疗效果均不理想。神经生长因子对周围神经和中枢神经都有营养作用,因此,本研究对临床爆震性耳聋患者进行了神经营养因子治疗,获得一定疗效,现报道如下: 1 资料与方法 1.1 一般资料 选取我院2006年2月～2009年2月的门诊患者19例(30耳),其中,男14例,女5例;年龄12～70岁;双耳听力下降11例(22耳),单耳听力下降8例(8耳)。30耳爆震伤中,鞭炮伤18耳,步枪打靶后伤2耳,隧道风镐声伤4耳,开山炸药爆震伤4耳,高压蒸汽管道爆裂伤2耳;病程长短不一,最短是爆震伤后4 d就诊,大多数患者是1个月后就诊,最晚是爆震伤后6个月来诊。 1.2 听力