brain morphological signatures for chronic pain大脑形态学特征为慢性疼痛.pdfVIP

Brain Morphological Signatures for Chronic Pain 1 2 3 1,4,5 Marwan N. Baliki , Thomas J. Schnitzer , William R. Bauer , A. Vania Apkarian * 1 Department of Physiology, Northwestern University, Chicago, Illinois, United States of America, 2 Department of Physical Medicine and Rehabilitation, Northwestern University, Chicago, Illinois, United States of America, 3 Department of Neuroscience, University of Toledo, Toledo, Ohio, United States of America, 4 Department of Anesthesia, Feinberg School of Medicine, Chicago, Illinois, United States of America, 5 Department of Surgery, Feinberg School of Medicine, Chicago, Illinois, United States of America Abstract Chronic pain can be understood not only as an altered functional state, but also as a consequence of neuronal plasticity. Here we use in vivo structural MRI to compare global, local, and architectural changes in gray matter properties in patients suffering from chronic back pain (CBP), complex regional pain syndrome (CRPS) and knee osteoarthritis (OA), relative to healthy controls. We find that different chronic pain types exhibit unique anatomical ‘brain signatures’. Only the CBP group showed altered whole-brain gray matter volume, while regional gray matter density was distinct for each group. Voxel-wise comparison of gray matter density showed that the impact on the extent of chronicity of pain was localized to a common set of regions across all conditions. When gray matter density was examined for large regions approximating Brodmann areas, it exhibited unique large-scale distributed networks for each group. We derived a barcode, summarized by a single index of within-subject co-variation of gray matter density, which enabled classi