carboxyl-terminal truncated hbx regulates a distinct microrna transcription program in hepatocellular carcinoma development羧基末端截断hbx调节不同的微rna转录程序在肝细胞癌的发展.pdfVIP

Carboxyl-Terminal Truncated HBx Regulates a Distinct MicroRNA Transcription Program in Hepatocellular Carcinoma Development 1,2 1 1,2 3 Wing-Kit Yip , Alfred Sze-Lok Cheng *, Ranxu Zhu , Raymond Wai-Ming Lung , Daisy Pui-Fong 1,2 1 2¤a 1,2 1,4 Tsang , Suki Shuk-Kei Lau , Yangchao Chen , Jonathan Gabriel Sung , Paul Bo-San Lai , Enders 1¤b 1,2 3 1,3 1,2 1,2 Kai-On Ng , Jun Yu , Nathalie Wong , Ka-Fai To , Vincent Wai-Sun Wong , Joseph Jao-Yiu Sung , Henry Lik-Yuen Chan1,2 1 Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China, 2 Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China, 3 Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China, 4 Department of Surgery, The Chinese University of Hong Kong, Hong Kong SAR, China Abstract Background: The biological pathways and functional properties by which misexpressed microRNAs (miRNAs) contribute to liver carcinogenesis have been intensively investigated. However, little is known about the upstream mechanisms that deregulate miRNA expressions in this process. In hepatocellular carcinoma (HCC), hepatitis B virus (HBV) X protein (HBx), a transcriptional trans-activator, is frequently expressed in truncated form without carboxyl-terminus but its role in miRNA expression and HCC development is un