diabetes and the risk of multi-system aging phenotypes a systematic review and meta-analysis糖尿病和多系统衰老表型的风险系统回顾和荟萃分析.pdfVIP

Diabetes and the Risk of Multi-System Aging Phenotypes: A Systematic Review and Meta-Analysis Feng-Ping Lu1,2, Kun-Pei Lin1,3, Hsu-Ko Kuo1,4,5* 1 Department of Geriatrics and Gerontology, National Taiwan University Hospital, Taipei, Taiwan, 2 Institute of Health Policy and Management, College of Public Health, National Taiwan University, Taipei, Taiwan, 3 Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan, 4 Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, 5 Division of Gerontology Research, National Health Research Institutes, Taipei, Taiwan Abstract Background: Observational studies suggested an association between diabetes and the risk of various geriatric conditions (i.e., cognitive impairment, dementia, depression, mobility impairment, disability, falls, and urinary incontinence). However, the magnitude and impact of diabetes on older adults have not been reviewed. Methodology/Principal Findings: MEDLINE and PSYCINFO databases were searched through November 2007 for published studies, supplemented by manual searches of bibliographies of key articles. Population-based, prospective cohort studies that reported risk of geriatric outcomes in relation to diabetes status at baseline were selected. Two authors independently extracted the data, including study population and follow-up duration, ascertainment of diabetes status at baseline, outcomes of interest and their ascertainment, adjusted covariates, measures of association, and brief results. Fifteen studies examined the association of DM with cognitive dysfunction. DM was associated with a faster decline in cognitive function among older adults. The pooled adjusted risk ratio (RR) for all dementia when persons with DM were compared to those without was 1.47 (95% CI, 1.25 to 1.73). Summary RRs for Alzheimer’s disease and vascular demen