dinosaur peptides suggest mechanisms of protein survival恐龙生存的蛋白质肽显示机制.pdfVIP

Dinosaur Peptides Suggest Mechanisms of Protein Survival 1 2,3,4 5 6,7 8,9 James D. San Antonio *, Mary H. Schweitzer , Shane T. Jensen , Raghu Kalluri , Michael Buckley , Joseph P. R. O. Orgel10* 1 Operations, Orthovita, Inc., Malvern, Pennsylvania, United States of America, 2 Department of Marine, Earth and Atmospheric Sciences, North Carolina State University, Raleigh, North Carolina, United States of America, 3 North Carolina Museum of Natural Sciences, Raleigh, North Carolina, United States of America, 4 Museum of the Rockies, Montana State University, Bozeman, Montana, United States of America, 5 Department of Statistics, The Wharton School, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, 6 Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America, 7 Department of Biological Chemistry and Molecular Pharmacology, Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Boston, Massachusetts, United States of America, 8 Manchester Interdisciplinary Biocentre, Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom, 9 Department of Archaeology, The University of York, York, United Kingdom, 10 Department of Biology, Pritzker Institute of Biomedical Science and Engineering, Illinois Institute of Technology, Chicago, Illinois, United States of America Abstract Eleven collagen peptide sequences recovered from chemical extracts of dinosaur bones were mapped onto molecular models of the vertebrate collagen fibril derived from extant taxa. The dinosaur peptides localized to fibril regions protected