distinct contributions of the dorsolateral prefrontal and orbitofrontal cortex during emotion regulation不同的贡献的背外侧前额叶和前额皮质在情绪调节.pdfVIP

Distinct Contributions of the Dorsolateral Prefrontal and Orbitofrontal Cortex during Emotion Regulation 1,2 1,2,3 1,2 1,4 1 Armita Golkar *, Tina B. Lonsdorf , Andreas Olsson , Kara M. Lindstrom , Jonathan Berrebi , 1 5 1,2,6 ¨ 1,2,7 Peter Fransson , Martin Schalling , Martin Ingvar , Arne Ohman 1 Stockholm Brain Institute, Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden, 2 Nordic Center of Excellence in Cognitive Control, Stockholm, Sweden, 3 Institute for Systems Neuroscience, University Hospital Hamburg-Eppendorf, Hamburg, Germany, 4 Mood and Anxiety Program, National Institute of Mental Health, Bethesda, Maryland, United States of America, 5 Center for Molecular Medicine and Surgery, Karolinska Institutet, Solna, Sweden, 6 Osher Center for Integrative Medicine, Stockholm, Sweden, 7 NIH Center for the Study of Emotion and Attention, Gainesville, Florida, United States of America Abstract The lateral prefrontal and orbitofrontal cortices have both been implicated in emotion regulation, but their distinct roles in regulation of negative emotion remain poorly understood. To address this issue we enrolled 58 participants in an fMRI study in which participants were instructed to reappraise both negative and neutral stimuli. This design allowed us to separately study activations reflecting cognitive processes associated with reappraisal in general and activations specifically related to reappraisal of negative emotion. Our results confirmed that both the dorsolateral prefrontal cortex (DLPFC) and the lateral orbitofrontal cortex (OFC) contri