sensory nerve innervation of epineurial arterioles of the sciatic nerve containing calcitonin gene–related peptide effect of streptozotocin-induced diabetes坐骨神经的感觉神经支配的神经外小动脉包含降钙素相关基因肽体外糖尿病的效果.pdfVIP

Experimental Diab. Res., 5:187–193, 2004 c Copyright Taylor and Francis Inc. ISSN: 1543-8600 print / 1543-8619 online DOI: 10.1080/15438600490486732 Sensory Nerve Innervation of Epineurial Arterioles of the Sciatic Nerve Containing Calcitonin Gene–Related Peptide: Effect of Streptozotocin-Induced Diabetes M. A. Yorek, L. J. Coppey, J. S. Gellett, and E. P. Davidson Department of Internal Medicine, University of Iowa and Veterans Affairs Medical Center, Iowa City, Iowa, USA from these nerves regulate vascular tone and nerve blood flow The authors have determined that epineurial arteri- [1–4]. Previously, we reported that diabetes caused impairment oles of the sciatic nerve are innervated by nonadrenergic, in acetylcholine-mediated vasodilation in epineurial arterioles noncholinergic nerves that contribute to the regulation of of the sciatic nerve [5]. In the present study, we report that in- vasodilation. Using immunohistochemistry, the authors nervation by sensory nerves containing calcitonin gene–related determined that nerves innervating epineurial arterioles contain the neuropeptide calcitonin gene–related peptide peptide (CGRP) of epineurial arterioles of the sciatic nerve and (CGRP). Using streptozotocin-induced diabetic rats, the au- CGRP bioactivity is altered in streptozotocin-induced diabetic thors demonstrated that CGRP content in sensory nerves rats. Impairment in innervation by sensory nerves or vascular innervating epineurial arterioles and vasodilation in re- regulation could contribute to nerve ischemia and the progres- sponse to exogenous CGRP was decreased. In summary,