the ppar agonist fenofibrate reduces prepulse inhibition disruption in a neurodevelopmental model of schizophreniappar激动剂非诺贝特减少前脉冲抑制干扰在精神分裂症的神经发育模型.pdfVIP

Hindawi Publishing Corporation Schizophrenia Research and Treatment Volume 2012, Article ID 839853, 5 pages doi:10.1155/2012/839853 Research Article The PPARα Agonist Fenofibrate Reduces Prepulse Inhibition Disruption in a Neurodevelopmental Model of Schizophrenia 1, 2 1 2, 3 ´ 1 Benjamin Rolland, Kevin Marche, Olivier Cottencin, and Regis Bordet 1 Departement de Pharmacologie Medicale, EA 1046, Universite Lille Nord de France, 1 place de Verdun, 59000 Lille, France ´ ´ ´ 2 Service de Psychiatrie et Addictologie, CHU Lille, 59037 Lille, France 3 LNFP, EA4559, Universite Lille Nord de France, 59000 Lille, France ´ ´ Correspondence should be addressed to Regis Bordet, regis.bordet@univ-lille2.fr Received 13 January 2012; Revised 12 March 2012; Accepted 13 March 2012 Academic Editor: Anilkumar Pillai Copyright © 2012 Benjamin Rolland et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Oxidative stress has been implicated in neurodevelopmental theories of schizophrenia. Antioxidant Peroxysome Proliferator- Activated Receptors α (PPARα) agonist fenofibrate has neuroprotective properties and could reverse early preclinical infringements that could trigger the illness. We have evaluated the neuroprotective interest of fenofibrate in a neurodevelopmental rat model of schizophrenia. The oxidative