胆囊癌中Plk1和FoxM1的表达及其临床意义.docVIP

胆囊癌中Plk1和FoxM1的表达及其临床意义 王瑞涛,刘昌,吴齐飞,周磊,雷磊,曲凯,孟凡迪 （710061西安,西安交通大学医学院：第一附属医院肝胆外科） [摘要] 目的 探讨胆囊癌、癌旁及正常胆囊组织中Plk1（Polo-like Kinase 1）和FoxM1（Forkhead box M1）的表达及其与胆囊癌临床病理特征的关系，并探讨二者表达的相关性。方法 应用免疫组化SP法检测64例胆囊癌、癌旁和12例正常胆囊组织中Plk1和FoxM1蛋白的表达。结果 在胆囊癌、癌旁及正常胆囊组织中Plk1表达的阳性率分别为：65.6%、40.6%、8.3%，FoxM1表达的阳性率分别为：57.8%、32.8%、8.3%，Plk1和FoxM1在胆囊癌中的表达明显高于癌旁及正常胆囊组织，差异有统计学意义（P0.05）；Plk1和FoxM1在胆囊癌中表达与胆囊癌部分临床病理特征相关； Spearman等级相关性分析, Plk1和FoxM1的表达呈正相关关系（P0.05）。结论 Plk1和FoxM1在胆囊癌中的表达具有一定肿瘤特异性，有望成为胆囊癌治疗的新靶点。 [关键词] 胆囊癌;Plk1; FoxM1;免疫组化 [中图分类号] R735.8;R341;R730.2 [文献标识] A [文章编号] Expression and Clinical Significance of Plk1 and FoxM1 in Gallbladder Carcinoma WANG Ruitao,LIU Chang, WU qifei, ZHOU lei,LEI lei,QU kai,MENG fandi （Department of hepatobiliary surgery,the First Affiliated Hospital,School of Medicine, Xi’an Jiaotong University,Xi’an,Shaanxi Province,710061,China） [Abstract] Objective This study was to investigate the expression of Plk1（Polo-like Kinase 1）and FoxM1（Forkhead box M1） in gallbladder carcinoma、 ------------------------------------------------------------------- 作者简介：王瑞涛(1983 -)，男，医学博士，住院医师，研究方向:肝胆肿瘤. E-mail:wruitao2008@163.com通讯作者：刘昌（1967 -），女，医学博士，教授，从事肝胆外科专业研究. E-mail:eyrechang@126.compericarcinoma and healthy gallbladder tissues, and to explore their relationships with clinical pathology parameters of gallbladder carcinoma and the correlations between the two kinases. Methods SP immunohistochemistry staining was applied to detect the expressions of Plk1 and FoxM1 in 64 cases of gallbladder carcinoma and 12 cases of healthy gallbladder tissues. Results The Plk1 positive percentages was 65.6%、40.6% and 8.3% respectively in gallbladder carcinoma、pericarcinoma and healthy gallbladder tissues, while FoxM1 was 57.8%、32.8% and 8.3% respectively;The expressions of Plk1 and FoxM1 in gallbladder carcinoma were higher than those in pericarcinoma and healthy gallbladder tissues, and the differences of Plk1 and FoxM1 were significant (P0.05); The