acetylcholinesterase inhibitors (acheis) for the treatment of visual hallucinations in schizophrenia a review of the literature乙酰胆碱酯酶抑制剂(achei)治疗视觉幻觉的精神分裂症文献之回顾.pdfVIP

Patel et al. BMC Psychiatry 2010, 10:69 /1471-244X/10/69 REVIEW Open Access Acetylcholinesterase Inhibitors (AChEI’s) for the treatment of visual hallucinations in schizophrenia: A review of the literature 1 1 1 2* Sachin S Patel , Azizah Attard , Pamela Jacobsen , Sukhi Shergill Abstract Background: Visual hallucinations occur in various neurological diseases, but are most prominent in Lewy body dementia, Parkinson’s disease and schizophrenia. The lifetime prevalence of visual hallucinations in patients with schizophrenia is much more common than conventionally thought and ranges from 24% to 72%. Cortical acetylcholine (ACh) depletion has been associated with visual hallucinations; the level of depletion being related directly to the severity of the symptoms. Current understanding of neurobiological visual processing and research in diseases with reduced cholinergic function, suggests that AChEI’s may prove beneficial in treating visual hallucinations. This offers the potential for targeted drug therapy of clinically symptomatic visual hallucinations in patients with schizophrenia using acetylcholinesterase inhibition. Methods: A systematic review was carried out investigating the evidence for the effects of AChEI’s in treating visual hallucinations in Schizophrenia. Results: No evidence was found relating to the specific role of AChEI’s in treating visual hallucinations in this patient group. Discussion: Given the use of AChEI’s in targeted, symptom specific treatment in other neuropsychiatric disorders, it is surprising to find no related literature in schizophrenia patients. The use of AChEI’s in schizophrenia has investigated effects on cognition primarily with non cognitive effects measured more broadly. Conclusions: We