复方磺胺甲恶唑（Compound sulfamethoxazole）.docVIP

复方磺胺甲恶唑（Compound sulfamethoxazole） Compound sulfamethoxazole dispersible tablets Yu-an Qing Information Essential information [name of drug] Compound sulfamethoxazole dispersible tablets English Name: Compound, Sulfamethoxazole, Dispersible, Tablets Chinese Pinyin Name: Fufang Huanganjiaezuo Fensanpian Commodity name: Jade Emperor. [main ingredients] this product is a compound preparation, each containing sulfonamide active ingredients of sulfamethoxazole and trimethoprim in 0.08g 0.4g. [character] this product is white. [pharmacological toxicology] this product is sulfamethoxazole (SMZ) with exergy and trimethoprim (TMP) compound preparation, on enzyme production of Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Escherichia coli, Klebsiella, Salmonella, proteus sp., Morgan, Shigella other Enterobacteriaceae bacteria, Neisseria gonorrhoeae and Neisseria meningitis, Haemophilus influenzae has good antibacterial effect, especially antibacterial effect on Escherichia coli, Haemophilus influenzae, Staphylococcus aureus SMZ was significantly higher than single drug enhancement. In addition in vitro on Chlamydia trachomatis, Nocardia asteroids, protozoan, Toxoplasma gondii also has good anti microbial activity. The mechanism of the effect of SMZ on the first step of dihydrofolate synthase, interferes with the synthesis of folic acid, TMP second step in folic acid metabolism, selective inhibition of dihydrofolate reductase, a combination of the folic acid metabolism of bacteria by double blocking. The synergistic antibacterial action of this product was higher than that of single drug, and its resistant strains decreased. However, in recent years, the resistance of bacteria to this product has also increased. [pharmacokinetics] the SMZ and TMP in this product are absorbed from the stomach and intestines after oral administration, and can be absorbed more than 90% of the dosage. The peak concentration of serum (Cmax) is reached 1~4 hours after taki