CD4+CD25+调节性T细胞及其及GVHD关联性.docVIP

CD4+CD25+调节性T细胞及其及GVHD关联性 　【摘要】 CD4+CD25+调节性T细胞是一群表型和功能特异的T细胞亚群，具有免疫无能和免疫抑制两大特性，通过细胞直接接触或分泌抑制性细胞因子发挥对CD4+CD25-T细胞的抑制作用。GVHD是异基因造血干细胞移植最严重的并发症之一，近来有关CD4+CD25+调节性T细胞与GVHD关联性的研究得出了两种截然相反的结论，即该类细胞可有效防治GVHD的发生及该类细胞与GVHD的发生率成正比。这一研究结果的明确将为GVHD的临床治疗提供新的思路。本文就CD4+CD25+调节性T细胞及其免疫表型、特性、免疫调节作用机制及CD4+CD25+T细胞与GVHD的关联性的一些新的研究进展作一综述。 【关键词】 CD4+CD25+调节性T细胞 　　CD4+CD25+ Regulatory T Cells and Their Function in Graft- Versus-Host Disease ——Review 　　Abstract As a functionally and phenotypically distictive T cell subpopulation，CD4+CD25+ regulatory T cells are anergic and retain their ability to suppress antigen-driven response of CD4+CD25- cells in a contact-dependent manner or through a way of secreting immunosuppressive cytokines such as IL-10 and TGF-β.Graft-versus-host disease (GVHD) is one of the major complications following allogeneic hematopoietic stem cell transplantation (HSCT).Recently，some researches on the relationship between donor CD4+CD25+ regulatory T cells and GVHD severity produced two contradictory conclusions： one is CD4+CD25+ regulatory T cells that can prevent GVHD efficiently; the other is that GVHD is associated with the increased numbers of peripheral blood CD4+CD25+ regulatory T cells.The answer to this question will provide a new idea for clinic therapy of GVHD.In this review some new research progresses in the related area，such as the CD4+CD25+ regulatory T cells，the phenotype，characteristics，immunoregulatory mechanisms of CD4+CD25+ regulatory T cells，as well as the relation of CD4+CD25+ with GVHD were presented. 　　Key words CD4+CD25+ regulatory T cell; CD4+CD25- T cell; GVHD 异基因造血干细胞移植物中常常混含供者T淋巴细胞，这些细胞对受者同种异型抗原发生应答，而引发移植物抗宿主病（graft-versus-host disease，GVHD）。近年来人们发现了一类CD4+调节细胞，在诱导和维持自身耐受并预防治疗GVHD中可能有一定作用。其中CD4+CD25+调节性Ｔ细胞亚类是此类细胞中的主要组成成分。1995年日本学者Sakaguchi等［1］首次报道了CD4+CD25+调节性Ｔ细胞的存在，证实其是一群表型和功能特异的T细胞，在胸腺产生，在人类和鼠类的胸腺、淋巴组织和外周血中约占CD4+T细胞的5%-15%。本文拟对CD4+CD25+调节性Ｔ细胞的生物学特性及其在GVHD中所起作用的研究作一综述。 　　CD4+CD25+调节性T细胞 　　CD4+CD25+调节性T细胞的产生及其分化发育 　　CD4+CD25+调节性Ｔ细胞产生及其分化发