丙泊酚对50例骨关节结核患者炎症因子影响.docVIP

丙泊酚对50例骨关节结核患者炎症因子影响 　　摘 要 目的：探讨丙泊酚对骨关节结核患者的炎症因子的影响。方法：随机选取100例骨关节结核患者并分为丙泊酚组（接受丙泊酚治疗）和异氟烷组（接受异氟烷治疗）各50例，对比2组白细胞介素-1（IL-1）、肿瘤坏死因子-alpha;（TNF-a）、细胞间黏附分子-1（ICAM-1）和白细胞介素-6（IL-6）、白细胞介素-10（IL-10）的变化。结果：丙泊酚组患者术后12和24 h的IL-1、TNF-a、ICAM-1及T2时间点的IL-6水平均明显低于、而T2～T4各时间点IL-10水平则明显高于异氟烷组（Plt;0.01）。2组患者IL-6水平均从T0时间点逐渐上升至T3、IL-10水平从T0时间点逐渐上升至T2（丙泊酚组）或T3（异氟烷组）达到峰值后逐渐下降。结论：丙泊酚能有效抑制炎症因子TNF-a，IL-1和ICAM-1的释放，降低患者炎症反应的强度，亦能调节细胞因子IL-6和IL-10水平的平衡，减轻患者对手术的应激反应。　　关键词 丙泊酚 骨关节结核 IL-1 TNF-a　　中图分类号：R529.2； R971.2 文献标识码：B 文章编号：1006-1533（2016）17-0038-03　　Effect of propofol on inflammatory factors in 50 cases of patients with bone and joint tuberculosis*　　LIANG Junrong**　　（Department of Anesthesia， Xiushui Hospital of Traditional Chinese Medicine， Jiangxi 332000， China）　　ABSTRACT Objective： To observe and evaluate the effects of propofol on inflammatory factors in patients with bone and joint tuberculosis. Methods： One hundred cases of patients with bone and joint tuberculosis were randomly selected and divided into a propofol group （receiving propofol treatment） and an isoflurane group （receiving isoflurane treatment） with 50 cases each. The changes of the levels of interleukin -1 （IL-1）， tumor necrosis factor alpha （TNF-a）， intercellular adhesion molecule -1 （ICAM-1） and interleukin -6 （IL-6）， interleukin -10 （IL-10） were compared between two groups. Results： The levels of IL-1， TNF-a and ICAM-1 at postoperative 12 and 24 hour and the IL-6 level at T2 time point were significantly lower， while the IL-10 levels at T2-T4 time points were significantly higher in the propofol group than in the isoflurane group （Plt;0.01）. The IL-6 levels in two groups gradually increased from T0 time point to T3， and the IL-10 levels gradually increased from T0 time point to T2 （for the propofol group） or T3（for the isoflurane group） to reach the peak and then all gradually decreased （Plt;0.01）. Conclusion： Propofol can effectively inhibit the release of inflammatory factor TNF-a， IL-1 and ICAM-1， reduce the intens