原创力文档non-imprinted allele-specific dna methylation on human autosomesnon-imprinted allele-specific对人类常染色体dna甲基化.pdfVIP
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non-imprinted allele-specific dna methylation on human autosomesnon-imprinted allele-specific对人类常染色体dna甲基化
Volume 10, Issue 12, Article R138Zhanget al.2009 Open Access
Research
Non-imprinted allele-specific DNA methylation on human
autosomes
* * †
Yingying Zhang , Christian Rohde , Richard Reinhardt , Claudia Voelcker-
Rehage‡ and Albert Jeltsch*
Addresses: *School of Engineering and Science, Jacobs University Bremen, Campus Ring 1, D-28759 Bremen, Germany. †Max Planck Institute
for Molecular Genetics, Ihnestrasse 63-73, D-14195 Berlin-Dahlem, Germany. ‡Jacobs Center on Lifelong Learning and Institutional
Development, Jacobs University Bremen, Campus Ring 1, D-28759 Bremen, Germany.
Correspondence: Albert Jeltsch. Email: a.jeltsch@jacobs-university.de
Published: 3 December 2009 Received: 17 July 2009
Revised: 23 October 2009
Genome Biology 2009, 10:R138 (doi:10.1186/gb-2009-10-12-r138)
Accepted: 3 December 2009
The electronic version of this article is the complete one and can be
found online at /2009/10/12/R138
© 2009 Zhang et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which
permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Allele-specific CpG methylationreflecting differences in gene expression./ppSingle-nucleotide polymorphisms located within CpG islands are found to cause differences in CpG methylation between alleles,
Abstract
Background: Differential DNA methylation between alleles is well established in imprinted genes
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