原创力文档selenium as an essential micronutrient roles in cell cycle and apoptosis硒作为一种必不可少的微量营养素的角色在细胞周期和细胞凋亡.pdfVIP
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selenium as an essential micronutrient roles in cell cycle and apoptosis硒作为一种必不可少的微量营养素的角色在细胞周期和细胞凋亡
Molecules 2009, 14, 1263-1278; doi:10.3390/molecule
OPEN ACCESS
molecules
ISSN 1420-3049
/journal/molecules
Review
Selenium as an Essential Micronutrient: Roles in Cell Cycle and
Apoptosis
Huawei Zeng
United States Department of Agriculture, Agricultural Research Service, Grand Forks Human
Nutrition Research Center, Grand Forks, North Dakota 58202-9034, USA; E-mail:
huawei.zeng@; Tel.: +1-7017958465; Fax: +1-7017958220.
Received: 30 January 2009; in revised form: 15 February 2009 / Accepted: 20 March 2009 /
Published: 23 March 2009
Abstract: Selenium is an essential trace element for humans and animals, and selenium
deficiency is associated with several disease conditions such as immune impairment. In
addition, selenium intakes that are greater than the recommended daily allowance (RDA)
appear to protect against certain types of cancers. In humans and animals, cell proliferation
and death must be regulated to maintain tissue homeostasis, and it has been well
documented that numerous human diseases are directly related to the control of cell cycle
progression and apoptosis. Thus, the elucidation of the mechanisms by which selenium
regulates the cell cycle and apoptosis can lead to a better understanding of the nature of
selenium’s essentiality and its role in disease prevention. This article reviews the status of
knowledge concerning the effect of selenium on cell cycle and apoptosis.
Keywords: Selenium; Cell proliferation; Cell cycle; Apoptosis;
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