13C尿素呼气实验用于慢性幽门螺旋杆菌感染及脑梗死关系探究.docVIP

13C尿素呼气实验用于慢性幽门螺旋杆菌感染及脑梗死关系探究 　【摘要】 目的： 用无创性检测慢性幽门螺旋杆菌（Helicobacter pylori，Hp）感染的方法（13C尿素呼气实验），探讨慢性Hp感染与急性脑梗死的相关性及可能的作用机制。 方法： 用13C尿素呼气实验检测82例急性脑梗死患者及78例对照患者的Hp感染情况。 结果： 急性脑梗死组有20例Hp阳性，Hp的感染率为238%；对照组有6例Hp阳性，Hp的感染率为 77%。 结论： ①急性脑梗死患者的Hp感染率比对照组高（Plt;001）；②与国内外诸多研究不同的是我们用13C尿素呼气实验检测慢性Hp感染，结果是其感染率明显低于用其它方法检测的结果（病例组与对照组均低），其原因可能是在大多数研究中，采用血清学方法检测Hp抗体IgG、IgA、IgM来诊断慢性Hp感染，假阳性率高；③慢性Hp感染可能通过多种机制导致急性脑梗死的发生。 【关键词】 脑梗死； 幽门螺旋杆菌； 13C尿素呼气实验 The Study on Relationship between Acute Cerebral Infarction and Chronic Helicobacter Pylori（Hp）Infection with 13CUREABreath Test YU Aimei, ZOU Yuan Department of Neurology, The First Affiliated Hospital, Hebei North University, Zhangjiakou, 075000, Hebei China 【ABSTRACT】 Objective: To investigate chronic Helicobacter pylori（Hp） infection with the advanced test method without trauma, so as to explore the relationship between acute cerebral infarction and chronic Hp infection. Methods: Chronic Hp infection in 82 patients with acute cerebral infarction was tested with 13CUREABreath method. Results: There were 20 Hp positive in 82 acute cerebral infarction patients and the incidence was 238%. And there were 6 Hp positive in 78 in control group, the incidence was 77%（Plt;001）. Conculsion: ① There are much more differences between our study and other studies in our country or other countries. Other studies indicate the percentage of Hp infection is very high, but when tested with chronic Hp infection with 13CUREABreath test, the results indicate the percentage of Hp infection is lower obviously in both acute cerebral infarction group and control group. Maybe the reason for this is that serologic method is used to test the antibody of HP, such as IgG, IgA, IgM, so the pseudopositive is very high. ② The percentage of Hp infection is higher in acute cerebral infarction group than that of control group. ③ Chronic Hp infection as a risk factor for acute cerebral infarction, there may be several pathogenesis between chronic Hp infection and acute c