生物反应工程教学课件-Bioprocess Engineering Lesson-6.pptVIP

* Mass balance for oxygen at steady-state: We can use Eq. (7.27) to predict the response of the fermenter to changes in mass-transfer operating conditions. For example, if the rate of cell metabolism remains unchanged but kLa is increased by raising the stirrer speed to reduce the thickness of the boundary layer around the bubbles, the dissolved-oxygen concentration CAL must rise in order for the left-hand side to remain equal to the right-hand side. Similarly, if the rate of oxygen consumption by the cells accelerates while kLa is unaffected, CAL must decrease. * Further, we can deduce some