中医证型及高血压病患者血浆同型半胱氨酸及血脂关系临床探究.docVIP

中医证型及高血压病患者血浆同型半胱氨酸及血脂关系临床探究 　 作者：张玲端 任幼红 马兴荣 【摘要】; 　　［目的］探讨中医证型与高血压病（EH）患者血浆同型半胱氨酸（HCY）及血脂的关系。［方法］将343例患者按中医辨证分为肝火亢盛、阴虚阳亢、阴阳两虚、气虚痰浊四型，用荧光偏振免疫法检测EH患者与健康对照组血浆HCY水平，并检测血脂水平。［结果］EH患者血浆HCY水平显著高于健康对照组（P＜0.01），气虚痰浊型血浆HCY及LP（a）（脂蛋白a）水平显著高于健康对照组（P＜0.01），且气虚痰浊型血浆HCY与LP（a）水平呈正相关（r=0.2676，P＜0.01）。［结论］血浆HCY水平异常增高是EH的重要危险因素之一，EH患者血浆HCY及LP（a）水平显著增高且呈正相关可作为中医证型气虚痰浊型的辨证指标。 【关键词】; 同型半胱氨酸 高血压病 中医证型 血脂 冠心病 　　Abstract：［Objective］ To study the relation between essential hypertension （EH） and TCM syndrome types and Plasma homocysteine（Hcy）and lipid.［Method］343 cases of essential hypertension were divided into following syndromes：Liverfire hyperactivity，hyperactivity of Yang due to Yin deficiency，deficiency of Yin and Yang，Qideficiency and stagnation of phlegm.Plasma homocysteine and lipid in the patients of EH and the normal persons were detected with Fluorescenoe Polarization Immunoassay（FPIA）.［Result］Hcy level in the patients of EH was significantly higher than that of healthy controls（P＜0.01），Hcy and lipoprotein（a） level in the hypertensive patients with Qideficiency and stagnation of phlegm syndrome was significantly higher than those of healthy controls and liverfire hyperactivity （P＜0.01）.There was positive correlation between Hcy and lipoprotein（a） level in the hypertensive patients with Qideficiency and stagnation of phlegm syndrome（r=0.2676，P＜0.01）.［Conclusion］Abnormal increase of plasma Hcy level is a risk factor of EH，the significant increase and positive correlation of plasma Hcy and lipoprotein（a） level are a Chinese medical pattern identification index of the patients with Qideficiency and stagnation of phlegm. 　　Key words：homocysteine；hypertension；TCM syndrome types;lipid;coronary heart disease ; 　　血脂水平增高是冠心病、高血压病（EH）的危险因素之一，已为国内外医学界所公认，近年来同型半胱氨酸（HCY）水平增高是冠心病、EH的危险因素之一，也为国内外医学界大量资料证实［13］。为探讨中医证型与EH患者血浆HCY及血脂水平的关系，我们对343例EH例患者进行了临床研究。 　　1; 资料与方法 　　1.1; 研究对象; 343例EH患者均为我院2006年6月至2007年6月门诊及住院患者。男212例，女131例，年龄30～75岁，平均（65.63±5.6）岁。健康对照组为我院健康体检者80例，男56例，女24例，年龄30～76