噻唑烷化合物YFZ-22对A549细胞作用机制研究.pdfVIP

Abstract Background and objective Lung cancer, a kind of serious disease that is threatening human health with high morbidity and mortality, has become the leading cause of death from cancer. At present the chemotherapy is the most common treatment of lung cancer, but the existing drugs for the treatment of lung cancer is often easy to cause strong toxicity side effect and drug resistance. Therefore, it is extremely important for the treatment of lung cancer to search for chemotherapeutic drugs which are of high efficient and less toxicity side effects and can effectively overcome the multidrug resistance. In recent years, with the stud y of the thiazolidine compounds, people found that it has a broad spectrum of biological activities and are widely used in agriculture, chemistry, medicine, biology and many other fields. The thiazolidine compounds can induce differentiation and apoptosis in a variety of tumor cells, showing a good application prospect in cancer therapy areas. For example, MMPT and DBPT can affect the cell cycle and induce apoptosis pathway in lung adenocarcinoma cells to inhibit the growth of cancer cells. In view of the fact that the thiazolidine compounds showed anti-tumor activity in lung adenocarcinoma cells and potential applications in non-small cell lung cancer, we chose YFZ-22 as the study drug, which is one kind of novel thiazolidine compounds. In order to offer a theoretical basis for the treatment of lung cancer, we lead YFZ-22 into A549 cells to detect anti-tumor activity and investigate the mechanisms of the drugs. Methods 1. In vivo anti-tumor detection: - T