盐酸地尔硫卓注射液（Diltazem Hydrochloride Injection）.docVIP

盐酸地尔硫卓注射液（Diltazem Hydrochloride Injection） Diltazem Hydrochloride Injection The main ingredients of this product are: diltiazem hydrochloride. [traits] [pharmacology and toxicology] This product is a calcium channel blocker, which is related to the inhibition of calcium influx during the depolarization of the myocardium or vascular smooth muscle membrane. The effect and mechanism of anti angina: This product can make coronary artery dilatation epicardium and endocardium, spontaneous remission or by ergonovine induced coronary artery spasm caused by angina pectoris; in exertional angina, the expansion of peripheral blood vessels, reduce blood pressure, reduce the hearts workload, thus reducing the need for oxygen, improve blood pressure double product and heart rate, increase exercise tolerance and relieve angina. Used to treat high blood pressure, this product relaxes the vascular smooth muscle, reduces peripheral vascular resistance, decreases blood pressure, and is not accompanied by reflex tachycardia. This product inhibits the slow calcium channel of cardiac myocytes and makes the sinoatrial node and the atrioventricular node self disciplined and less conductive, so it is used in the therapeutic room. Because this product can improve left ventricular diastolic function, it can be used to treat hypertrophic cardiomyopathy. [pharmacokinetics] The distribution phase half-life (T1/2b) of intravenous injection was 1.9 hours. [indications] The ventricular rate can be used to control atrial fibrillation. [usage and dosage] Intravenous injection. Adult dosage, initial 10mg, before using Sodium Chloride Injection or Glucose Injection dissolved and diluted to 1% concentration, in 3 minutes slow injection, or according to the weight of 0.15 ~ 0.25mg/kg dose calculation, 15 minutes after repeated, can also according to the weight per minute 5 ~ 15mg/kg intravenous drip. [adverse effects] A placebo controlled trial of angina pectoris abroad showed that the product was no mo