(生物工艺学双语课件）Chapter 12Antibiotics.ppt

Chapter 12 Antibiotics An example of a penicillin fermentation medium * * Production of penicillin Penicillin G: benzylpenicillin Penicillin V: phenoxymethypenicillin Strain: Penicillium notatum (1940s) Penicillium chrysogenum 6-APA 12.1 Penicillin biosynthesis Side chain precursor Phenykacetate or phenoxyacetate Antifoam and source of C/energy Maize oil Buffer and source of P H3PO4 Buffer and source of Ca 2+ Ca2CO3 Source of N and S (NH4)2SO4 Source of N, energy and growth factors CSL or PharmaMedia C/energy source Sugar Function Componen