大孔树脂吸附地黄梓醇的特性.pdfVIP

大孔树脂吸附地黄梓醇的特性 ， ， ， 1 2 3 1 1 1 1 ∗1 2 樊海燕 ，杨坤 ，何宁 ，王远鹏 ，孙道华 ，李清彪 （1.厦门大学化学化工学院化学工程与生物工程系，福建厦门 361005 ；2.福建省化学生物学省重点实验室， 福建厦门 361005 ；3.江西中烟工业公司，江西南昌 330096 ） 摘要：本文研究了大孔树脂对地黄中梓醇的吸附分离特性。选择10 种不同极性大孔吸附树脂，比较其对梓 醇的吸附率和解吸率，筛选出最佳种类，并对其动力学曲线、吸附等温线以及动态吸附性能进行了考察。 结果表明：H103 树脂对梓醇有较好的吸附和解吸效果；其吸附等温线符合Langmuir 和Freundlich 吸附等 温式；其分离纯化梓醇的最佳工艺条件为：上柱液浓度为6.15 mg·mL-1 ，上柱液流速为1.0 mL·min-1 ，洗脱 剂为70% 乙醇，洗脱流速为0.5 mL·min-1 ，洗脱体积为3.33 BV （Bed Volume ）。经H103 树脂纯化后梓醇纯 度达到62.39 ％。 关键词：地黄；梓醇；大孔树脂 中图分类号：TQ 028.8 文献标识码：A 文章编号： Separation of Catalpol from Radix Rehmanniae Libosch by Macroporous Resin 1,2,3 1 1 1 1 ∗1,2 FAN Haiyan ，YANG Kun ，HE Ning ， WANG Yuanpeng ，SUN Daohua ，LI Qingbiao (1 Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian Province, and 2 Key Lab for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian Province, and 3 China Tobacco Jiangxi Industrial Corporation, Nanchang, Jiangxi Province. ） Abstract: The adsorption capacities and desorption yields of ten kinds of macroporous resins for catalpol were comparatively investigated. The results showed that H103 resin possessed the best performance, and its isotherm curve can be well described by Langmuir and Freundlich equation. The properties of dynamic adsorption and desorption of H103 resin for catalpol were subsequently investigated on column. The optimum conditions for adsorption and desorption were as follows: