八年制讲课佝偻病.ppt

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八年制讲课佝偻病

Rickets of Vitamin D Deficiency Tetany of Vitamin D Deficiency Chen Qiuli Attending Doctor Pediatric department The first affiliated hospital of Sun Yat-sen University Rickets Rickets of Vitamin D Deficiency Introduction Physiological function and regulation of VitD Etiology Pathology Pathogenesis Clinical manifestations Diagnosis Differential diagnosis Prevention Treatment Tetany of VitD Deficiency Rickets ---failure in mineralization of growing bone or osteoid tissue (children) the end of long bone, shaft Osteomalacia--mature bone (adults) Rickets of Vitamin D deficiency --- chronic systemic nutrition-deficient disease (2y) Rickets of Vitamin D Deficiency Introduction Physiological function and regulation of VitD Etiology Pathology Pathogenesis Clinical manifestations Diagnosis Differential diagnosis Prevention Treatment Tetany of VitD Deficiency Factors associated with Ca ,P metabolism and bone development *VitD(Vitamin D) important in mineralization of newly formed osteoid *PTH(parathormone,甲状旁腺素) *CT(calcitonine,降钙素) Physiological function of VitD *antirachitic function facilitation intestinal absorption of Ca , P(CaBP) reabsorption of Ca P in the kidneys direct effect on mineral metabolism of bone (deposition and reabsorption) * nonantirachitic function cell proliferation, differenciation, immunity Metabolism and regulation of VitD 7-dehydrocholesterol irradiated ergosterol Provitamin (skin) (plant) photochemically activation diet cholecalciferol calciferol (VitD3) (VitD2) 2

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