多奈哌齐对阿尔茨海默病患者尿中AD7c-NTP的影响.docVIP

精品论文 参考文献 多奈哌齐对阿尔茨海默病患者尿中AD7c-NTP的影响 张延霞1 崔瑞耀2（通讯作者） 王利群1 苏玉文1 （1解放军第88医院老年病科 山东泰安 271000） （2青岛大学医学院病理生理教研室 山东青岛 266000） 【摘要】目的 观察多奈哌齐对AD患者尿液AD7c-NTP的影响，并观察治疗前后MMSE评分的变化。 方法 选择2010.2～2013.10我科收治的AD患者40例，分为多奈哌齐治疗组（即治疗组）20例和对照组20例，其中治疗组男14例,女6例；对照组男15例,女5例，两组均给予尼莫地平、相同的活血化瘀药物等常规治疗及对症处理,治疗组在此基础上给予口服多奈哌齐，治疗前及治疗后24W行尿液AD7c-NTP检测及MMSE评分。结果 24W后，治疗组较对照组患者的AD7c-NTP水平显著降低（Plt;0.05），MMSE 评分显著升高（Plt;0.05）。结论 多奈哌齐治疗AD疗效显著， 无明显不良反应，临床中值得推广。 【关键词】多奈哌齐 AD 尿液AD7c-NTP 【中图分类号】R96 【文献标识码】A 【文章编号】2095-1752（2014）07-0064-02 Effect of donepezil on AD7c-NTP in urine of patients with Alzheimers disease ZHANG Yan-xia,SU Yu-wen,WANG Li-qun,SONG Yu-min ,Department of Cadre,the 88th Hospital of PLA,Tairsquo;an,271000,China 【Abstract】 Objective To observe the effect of donepezil orally on urine AD7c-NTP in patients with AD, and observe the change of MMSE score before and after treatment. Methods Choose 2010.2 to 2013.10 in our hospital from 40 AD patients, divided into in the treatment group (treatment group) 20 cases and control group 20 cases, the treatment group male 14 cases, female 6 cases; control group, male 15 cases, female 5 cases, the two groups were given nimodipine, the same blood circulation drugs routine treatment and symptomatic treatment, the treatment group was given based on oral donepezil, before and after 24W treatment for urinary AD7c-NTP detection and MMSE score. Results After 24W, the treatment group was significantly lower than the control group, the levels of AD7c-NTP in patients with (Plt;0.05), MMSE score was significantly increased (Plt;0.05).Conclusion Donepezil significant efficacy in the treatment of AD, no significant adverse reactions, worthy of promotion in clinical therapy. 【Key words】 Donepezil AD Urine 7c-NTP 阿尔茨海默病（ＡＤ）是一种年龄相关的以进行性认知功能障碍为特征的脑变性疾病。在ＡＤ神经元退行性变过程中，AD 相关神经丝蛋白( Alzheimer-associated n