妊娠高血压患者的血脂变化及临床意义.docVIP

精品论文 参考文献 妊娠高血压患者的血脂变化及临床意义 王 磊 雷晚红（咸宁市第一人民医院妇产科 湖北咸宁 437000） 【中图分类号】R714.2【文献标识码】A【文章编号】1672-5085（2012）5-0100-03 【摘要】目的 探讨妊娠高血压患者血脂的变化及其临床意义。方法 选择妊娠高血压患者、正常妊娠者、正常未孕者各40例，测定并比较血脂指标的变化。结果与正常未孕组相比，妊娠高血压疾病组和正常妊娠组血清TC、TG、HDL-C、LDL-C、ApoAI、ApoB、Lp(a)等指标均显著增高(Plt;0.01)；妊娠高血压疾病组与正常妊娠组相比，TG、LDL-C、ApoB显著增高(Plt;0.01)，而ApoAI却显著减低(plt;0.01)，TC和Lp(a)明显增高(plt;0.05)，而HDL-C却明显减低(plt;0.05)。结论 妊娠高血压孕妇存在明显的血脂代谢异常，妊娠期间定期监测LDL-C、ApoA/ApoB比值及Lp(a)的变化，对预测妊娠高血压的发生、发展有一定临床意义。 【关键词】妊娠高血压疾病 血脂 载脂蛋白 脂蛋白 Serum Lipids Changes and Itrsquo;s Clinical Significances in Patients with Pregnance-induced Hypertension WANG Lei；LEI Wan-hong （Department of Gynecology and Obstetrics，First Peoplersquo;s Hospital of Xianning City，Hubei Xianning 437000） 【Abstract】Objective：To investigate the serum lipids changes and their clinical siginificance in patients with pregnance-induced hypertension. Methods：This study was divided into pregnance-induced hypertension group，normal pregnaney group and normal non-pregnant group，there were 40 cases in each group. The serum lipids were determined and compared among each group.Results：Compared with normal non-pregnant group，the lvelels of TC,TG,LDL-C,HDL-C,ApoAI,ApoB and Lp(a) were increased obviously in pregnance-induced hypertension group and normal pregnaney group (P＜0.01). And levels of TG,LDL-C,ApoB were siginificantly higher in pregnance-induced hypertension group than normal pregnaney group(P＜0.01). While ApoAI and HDL-C were markedly reduced，TC and Lp(a) increased clearly(P＜0.05). Conclusions: There is obvious abnormal lipid metabolism in patients with pregnance-induced hypertension. Therefor，it has certain clinical significances of forecasting the occurrence and developing of pregnance-induced hypertension by monitoring the changes of serum lipids during pregnance，especially the changes of serum LDL-C，ApoAI/ApoB and Lp(a). 【Key words】hypertensive disorder complicating pregnancy blood lipid apolipoprotein lipoprotein 妊娠期高血压疾病（hypertensive disord