TNF-α基因多态性与慢性HBV感染研究进展.pdfVIP

·98· ·综述· TNF一0【基因多态性与慢性HBV感染研究进展 邱冰李庆华李东复 【摘要】肿瘤坏死阕子．a(TNF-a)是人体重要的免疫调节因子，在炎症反应和免疫应答中起重要 作用。研究发现，TNF．d基因启动子单核苷酸多态性影响TNF．0【的表达。在HBV感染中，TNF．d主要 是通过直接抑制病毒复制和间接调节宿主免疫应答发挥作用。TNF．d启动子区基因多态性必然导致不 同HBV感染者外周血单个核细胞和肝组织TNF．Ot表达水平间的差异，从而与HBV的慢性持续感染相 关。 【关键词】肿瘤坏死因子一or；多态性；HBV；慢性；感染 chronicHBV Tumournec瑚isfactor-d and infection genepolymorphism QIUBing+，LIQing—hun。LI Province Dong-fu．‘DepartmentofGastroenterologyHei—LongfiangHospital，Harbin150036，China Correspondingauthor：LiDong-fu，E-mail：Idt908@sina．eom necrosis a roleininflammationandimmune肛 【Abst腿ct】TNF一0【(tumourfactor-a)playspivotal as all humanimmune studiesindicatedthatthe fortheTNF—d sponse important regulator．Some capacity pro- ductioninindividuals on inthedefensea· largelydependspromotergeneticpolymorphisms．TNF—aparticipates Bviral inhibitionofviral determi— thwugh gainsthepatitisinfection，directlythrough replication，andindirectly nationofthe ofthehost leadtodif- predominantpattern response．Thepromotergeneticpolymorphismssurely ferent liver ofHBVinfection are8880— levelin bloodand tissues individuals．thus TNF一0【expressionperipherial ciatedwiththechronicHBV of its infection．Here，thestructure，function，andgenepolymorphismTNF·a，and withHBV relationship chronicinfectionwillbereviewed． 【Keywords】TNF-Ot；Polymorphism；HBV；Chronic；Infection B 全球慢性乙型肝炎病毒(hepatitisvirus， 毒复制和间接调节宿主免疫应答发挥作用HJ。肿